Impaired wound healing associated with recurrent Staphylococcus aureus infection and
unresolved inflammation are hallmarks of nonhealing diabetic foot ulcers (DFUs). Perforin-2 …

Nonhealing diabetic foot ulcers (DFU), a major complication of diabetes, are associated with
high morbidity and mortality despite current standard of care. Since Staphylococcus aureus …

Staphylococcus aureus triggers inflammation through inflammasome activation and
recruitment of neutrophils, responses that are critical for pathogen clearance but are …

Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to
infection, is a leading cause of death in intensive care units. The development of sepsis …

Background Osteomyelitis is a severe bone infection and typically leads to progressive bone
resorption, destruction and dysfunction. Pyroptosis is a form of programmed cell death …

Macrophages play a prominent role in wound healing. In the early stages, they promote
inflammation and remove pathogens, wound debris, and cells that have apoptosed. Later in …

Abstract Purpose of Review Diabetic foot ulcerations (DFU) affect 25% of patients with
diabetes mellitus during their lifetime and constitute a major health problem as they are often …

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. Recently was been found that pyroptosis is a unique form of …

Background Chronic inflammation is a characteristic feature of diabetic cutaneous wounds.
We sought to delineate novel mechanisms involved in the impairment of resolution of …

Diabetic foot ulceration (DFU) is a chronic complication of diabetes that is characterized by
impaired wound healing in the lower extremities. DFU remains a major clinical challenge …