Background. Islet transplantation is a promising option for the treatment of type 1 diabetes.
However, the current lack of practical techniques for the isolated islets preservation still …

Background A high yield of pure, viable islets is one of the most important prerequisites for
successful islet transplantation. However, during isolation and purification, many factors may …

Islet transplantation is an attractive treatment for type 1 diabetic patients. However,
transplanted islets suffered from considerable cell death due to inflammatory reactions and …

Islet transplantation is the experimental strategy to treat type 1 diabetes by transplanting
isolated islets from a donor pancreas into the recipient. While significant progress has been …

Induction of heme oxygenase-1 (HO-1) expression in recipients of allogeneic islets can lead
to long-term survival (> 100 d) of those islets. We tested whether administration of bilirubin …

Nonspecific inflammatory response is the major cause for failure of islet grafts at the early
phase of intraportal islet transplantation (IPIT). Bilirubin, a natural product of heme …

Pancreatic islet transplantation is the only curative, noninvasive treatment for type 1 diabetes
mellitus; however, high rates of cell death in the immediate postimplantation period have …

Bilirubin has been recognized as a powerful cytoprotectant when used at physiologic doses
and was recently shown to have immunomodulatory effects in islet allograft transplantation …

Islet cell transplantation has become a favorable therapeutic approach in the treatment of
Type 1 Diabetes due to the lower surgical risks and potential complications compared to …

Background and aims Successful islet transplantation as a promising treatment of diabetes
type 1 is threatened with the loss of islets during the pre-transplant culture due to hypoxia …