Advances in the biology and chemistry of sialic acids

X Chen, A Varki - ACS chemical biology, 2010 - ACS Publications
Sialic acids are a subset of nonulosonic acids, which are nine-carbon α-keto aldonic acids.
Natural existing sialic acid-containing structures are presented in different sialic acid forms …

Combinatorial chemoenzymatic synthesis and high-throughput screening of sialosides

HA Chokhawala, S Huang, K Lau, H Yu… - ACS chemical …, 2008 - ACS Publications
Although the vital roles of structures containing sialic acid in biomolecular recognition are
well documented, limited information is available on how sialic acid structural modifications …

Sialic acid O-acetylation: From biosynthesis to roles in health and disease

EA Visser, SJ Moons, SBPE Timmermans… - Journal of Biological …, 2021 - ASBMB
Sialic acids are nine-carbon sugars that frequently cap glycans at the cell surface in cells of
vertebrates as well as cells of certain types of invertebrates and bacteria. The nine-carbon …

[HTML][HTML] Sialic acid and biology of life: An introduction

S Ghosh - Sialic acids and sialoglycoconjugates in the biology of …, 2020 - ncbi.nlm.nih.gov
Sialic acids are important molecule with high structural diversity. They are known to occur in
higher animals such as Echinoderms, Hemichordata, Cephalochorda, and Vertebrata and …

Advanced chemical methods for stereoselective sialylation and their applications in sialoglycan syntheses

AM Vibhute, N Komura, HN Tanaka… - The Chemical …, 2021 - Wiley Online Library
Sialic acid is an important component of cell surface glycans, which are responsible for
many vital body functions and should therefore be thoroughly studied to understand their …

Achievements and challenges of sialic acid research

R Schauer - Glycoconjugate journal, 2000 - Springer
Sialic acids are one of the most important molecules of life, since they occupy the terminal
position on macromolecules and cell membranes and are involved in many biological and …

Sialic acids structure-analysis-metabolism-occurrence-recognition

G Reuter, HJ Gabius - BIOLOGICAL CHEMISTRY HOPPE SEYLER, 1996 - degruyter.com
Sialic acids are commonly positioned at non-reducing termini of complex carbohydrates.
Steady refinements of analytical techniques have enabled detailed mapping of the …

Sialic acid mimetics to target the sialic acid–Siglec axis

C Büll, T Heise, GJ Adema, TJ Boltje - Trends in biochemical sciences, 2016 - cell.com
Sialic acid sugars are vital regulators of the immune system through binding to
immunosuppressive sialic acid-binding immunoglobulin-like lectin (Siglec) receptors on …

Chemoenzymatic synthesis of GD3 oligosaccharides and other disialyl glycans containing natural and non-natural sialic acids

H Yu, J Cheng, L Ding, Z Khedri, Y Chen… - Journal of the …, 2009 - ACS Publications
In order to understand the biological importance of naturally occurring sialic acid variations
on disialyl structures in nature, we developed an efficient two-step multienzyme approach for …

Metabolic remodeling of cell‐surface sialic acids: Principles, applications, and recent advances

B Cheng, R Xie, L Dong, X Chen - ChemBioChem, 2016 - Wiley Online Library
Cell‐surface sialic acids are essential in mediating a variety of physiological and
pathological processes. Sialic acid chemistry and biology remain challenging to investigate …