Two highly selective μ-opioid receptor agonists, endomorphin-1 and endomorphin-2, have
been identified and postulated to be endogenous μ-opioid receptor ligands. We determined …

Two highly selective μ-opioid receptor agonists, endomorphin-1 and endomorphin-2, have
been identified and postulated to be endogenous ligands for μ-opioid receptors. Intrathecal …

Two highly selective m-opioid receptor agonists, endomorphin-1 (EM-1) and endomorphin-2
(EM-2), have been identified and postulated to be endogenous m-opioid receptor ligands …

We have previously demonstrated that the antinociception induced by either endomorphin-1
or endomorphin-2 given supraspinally is mediated by the stimulation of μ-opioid receptors …

We investigated the role of μ-opioid receptor subtypes in both endomorphin-1 and
endomorphin-2 induced antinociception in mice using supraspinally mediated behavior …

The antinociception induced by it or icv administration of endomorphins is mediated via μ-
opioid receptors. However, although endomorphins do not have an appreciable affinity for κ …

Rationale: Although there is evidence that central opioid receptors are involved in
immunomodulation, it has been only recently that an endogenous agonist, designated …

TWO highly-selective μ-opioid receptor agonists, endomorphin-1 and-2, were recently
purified from bovine brain and are postulated to be endogenous μ-opioid receptor ligands …

We have previously demonstrated that both endomorphin-1 and endomorphin-2 produce
their antinociception by the stimulation of μ-opioid receptors. However, the antinociception …

It is known that spinal morphine produces antinociception that is modulated by alpha 2-
adrenoceptors. Endomorphin-1, a newly-isolated endogenous opioid ligand, shows the …