The physicochemical properties and antitumor activity of dacarbazine, its analogs, and the
new alkylating agent imidazene are reviewed. It is shown that the activity of dacarbazine is …

Abstract Bis (2-chloroethyl) amino derivatives of imidazole, 4 (5)-aminoimidazol-5 (4)-
carboxamide, 4-nitro-5-thioimidazole, benzimidazole, and imidazolylpeptides are reviewed …

In a study on structure-activity relationship in 4 (or 5)-(alkyltriazeno) imidazole-5 (or 4)-
carboxamides, the antitumor activity of 4 (or 5)-(dialkyltriazeno) imidazole-5 (or 4) …

Several years ago the diazotization of 5-aminoimidazole-4-carboxamide was found to give
an internal diazonium salt, 5-diazoimidazole-4-carboxamide, which demonstrated marginal …

Abstract Acylation of 4‐carbamoylimidazolium‐5‐olate (2) with a variety of acid chlorides
produced 4 (5)‐carbamoyl‐1H‐imidazol‐5‐(4) yl acid carboxylates (3a‐j). Treatment of …

Abstract Several 5 (or 4)-(3-alkyl-3-methyl-1-triazeno) imidazole-4 (or 5)-carboxamides (III-
X) were prepared from 5-diazoimidazole-4-carboxamide and the appropriate N-alkyl …

The initial product of the diazotization of 5 (or 4)-aminoimidazole-4-(or 5 [-carboxamide has
been isolated and shown to be 5-diazoimidazole-4-carboxamide. The diazo derivative …

Several l-aryl-3, 3-dimethyltriazene derivatives have been synthesized and tested for their
antitumor activity against the TLX5 lymphoma in mice. These compounds are characterized …

Materials and Methods Animals and Tumor System Female mice of ddN strain weighing
20i2 g and Nakahara—Fukuoka sarcoma were used as reported previously.“The general …

First, we examined the substitution reaction of easily obtainable 3, 4, 5-trichloro-
pyridazine"?(TV) in order to synthesize the starting material, 4-methoxypyridazine (X). When …