Caloric restriction mimetics (CRMs) mimic the biochemical effects of nutrient deprivation by
reducing lysine acetylation of cellular proteins, thus triggering autophagy. Treatment with the …

Caloric restriction (CR) is currently the most robust environmental intervention known to
increase healthy life and prolong lifespan in several models, from yeast to mice. Although …

Nutrient depletion, which is one of the physiological triggers of autophagy, results in the
depletion of intracellular acetyl coenzyme A (AcCoA) coupled to the deacetylation of cellular …

Tumors and the immune system are intertwined in a competition where tilting the fine
balance between tumor‐specific immunity and tolerance can ultimately decide the fate of the …

Activated oncogenes and anticancer chemotherapy induce cellular senescence, a terminal
growth arrest of viable cells characterized by S-phase entry-blocking histone 3 lysine 9 …

Several environmental-associated stress conditions, including hypoxia, starvation, oxidative
stress, fast growth and cell death suppression, modulate both cellular metabolism and …

There is limited knowledge about the metabolic reprogramming induced by cancer therapies
and how this contributes to therapeutic resistance. Here we show that although inhibition of …

Mitochondria and endoplasmic reticulum (ER) share structural and functional networks and
activate well-orchestrated signaling processes to shape cells' fate and function. While …

Cancer cells gain growth advantages in the microenvironment by shifting cellular
metabolism to aerobic glycolysis, the so-called Warburg effect. There is a growing interest in …

Antineoplastic chemotherapies are particularly efficient when they elicit immunogenic cell
death, thus provoking an anticancer immune response. Here we demonstrate that …