[HTML][HTML] Immune modulation as a key mechanism for the protective effects of remote ischemic conditioning after stroke

S Abbasi-Habashi, GC Jickling, IR Winship - Frontiers in Neurology, 2021 - frontiersin.org
Remote ischemic conditioning (RIC), which involves a series of short cycles of ischemia in
an organ remote to the brain (typically the limbs), has been shown to protect the ischemic …

[HTML][HTML] Immune and inflammatory mechanism of remote ischemic conditioning: A narrative review

Y Xu, Y Wang, X Ji - Brain Circulation, 2023 - journals.lww.com
The benefits of remote ischemic conditioning (RIC) on multiple organs have been
extensively investigated. According to existing research, suppressing the immune …

Remote but not distant: a review on experimental models and clinical trials in remote ischemic conditioning as potential therapy in ischemic stroke

I Mollet, JP Marto, M Mendonça, MV Baptista… - Molecular …, 2022 - Springer
Stroke is one of the main causes of neurological disability worldwide and the second cause
of death in people over 65 years old, resulting in great economic and social burden …

Remote ischemic preconditioning‐mediated neuroprotection against stroke is associated with significant alterations in peripheral immune responses

ZJ Liu, C Chen, XR Li, YY Ran, T Xu… - CNS neuroscience & …, 2016 - Wiley Online Library
Aims Remote ischemic preconditioning (RIPC) of a limb is a clinically feasible strategy to
protect against ischemia–reperfusion injury after stroke. However, the mechanism …

Remote postischemic conditioning promotes stroke recovery by shifting circulating monocytes to CCR2+ proinflammatory subset

J Yang, M Balkaya, C Beltran, JH Heo… - Journal of …, 2019 - Soc Neuroscience
Brain injury from stroke is typically considered an event exclusive to the CNS, but injury
progression and repair processes are profoundly influenced by peripheral immunity. Stroke …

[HTML][HTML] Very delayed remote ischemic post-conditioning induces sustained neurological recovery by mechanisms involving enhanced angioneurogenesis and …

TR Doeppner, B Zechmeister, B Kaltwasser… - Frontiers in Cellular …, 2018 - frontiersin.org
Ischemic conditioning is defined as a transient and subcritical period of ischemia integrated
in an experimental paradigm that involves a stimulus of injurious ischemia, activating …

Per-and post-remote ischemic conditioning attenuates ischemic brain injury via inhibition of the TLR4/MyD88 signaling pathway in aged rats

J Lv, W Yan, J Zhou, H Pei, R Zhao - Experimental Brain Research, 2021 - Springer
Remote ischemic conditioning (RIC), as an emerging protective method, might be used
clinically to prevent ischemia–reperfusion injury (IRI) in ischemic stroke. In this study, we aim …

Neuroprotection by remote ischemic conditioning in the setting of acute ischemic stroke: a preclinical two-centre study

MV Basalay, M Wiart, F Chauveau, C Dumot, C Leon… - Scientific Reports, 2020 - nature.com
Reperfusion is the only existing strategy for patients with acute ischemic stroke, however it
causes further brain damage itself. A feasible therapy targeting reperfusion injury is remote …

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

Y Zhu, X Li, X Lei, L Tang, D Wen, B Zeng… - Neural Regeneration …, 2024 - journals.lww.com
Some studies have confirmed the neuroprotective effect of remote ischemic conditioning
against stroke. Although numerous animal researches have shown that the neuroprotective …

Neuroprotection by remote ischemic conditioning in rodent models of focal ischemia: a systematic review and meta-analysis

AJ Ripley, MS Jeffers, MW McDonald, J Montroy… - Translational Stroke …, 2021 - Springer
Remote ischemic conditioning (RIC) is a promising neuroprotective therapy for ischemic
stroke. Preclinical studies investigating RIC have shown RIC reduced infarct volume, but …