Targeting epigenetics for cancer therapy
JW Park, JW Han - Archives of pharmacal research, 2019 - Springer
Cancer can be identified as a chaotic cell state, which breaks the rules that govern growth
and reproduction, with main characteristics such as uncontrolled division, invading other …
and reproduction, with main characteristics such as uncontrolled division, invading other …
Epigenetic therapy of cancer: past, present and future
CB Yoo, PA Jones - Nature reviews Drug discovery, 2006 - nature.com
The initiation and progression of cancer is controlled by both genetic and epigenetic events.
Unlike genetic alterations, which are almost impossible to reverse, epigenetic aberrations …
Unlike genetic alterations, which are almost impossible to reverse, epigenetic aberrations …
[HTML][HTML] Novel epigenetic therapeutic strategies and targets in cancer
The critical role of dysregulated epigenetic pathways in cancer genesis, development, and
therapy has typically been established as a result of scientific and technical innovations in …
therapy has typically been established as a result of scientific and technical innovations in …
Clinical advances in targeting epigenetics for cancer therapy
S Feng, DD De Carvalho - The FEBS journal, 2022 - Wiley Online Library
The appropriate coordination between epigenetic regulators is essential for spatial and
temporal regulation of gene expression and maintenance of cell identity. Cancer is a …
temporal regulation of gene expression and maintenance of cell identity. Cancer is a …
Current paradigms in epigenetic anticancer therapeutics and future challenges
Any alteration at the genetic or epigenetic level, may result in multiplex of diseases including
tumorigenesis which ultimately results in the cancer development. Restoration of the normal …
tumorigenesis which ultimately results in the cancer development. Restoration of the normal …
[HTML][HTML] Epigenetic mechanisms as a new approach in cancer treatment: An updated review
Epigenetic, along with genetic mechanisms, is essential for natural evolution and
maintenance of specific patterns of gene expression in mammalians. Global epigenetic …
maintenance of specific patterns of gene expression in mammalians. Global epigenetic …
Cancer development, progression, and therapy: an epigenetic overview
S Sarkar, G Horn, K Moulton, A Oza, S Byler… - International journal of …, 2013 - mdpi.com
Carcinogenesis involves uncontrolled cell growth, which follows the activation of oncogenes
and/or the deactivation of tumor suppression genes. Metastasis requires down-regulation of …
and/or the deactivation of tumor suppression genes. Metastasis requires down-regulation of …
Epigenetic-based therapies in cancer: progress to date
Epigenetic gene silencing is a hallmark of cancer cells. Two important types of epigenetic
changes are DNA methylation and histone modification. These modifications are catalysed …
changes are DNA methylation and histone modification. These modifications are catalysed …
The promise of epigenetic therapy: reprogramming the cancer epigenome
Epigenetics refers to heritable molecular determinants of phenotype independent of DNA
sequence. Epigenetic features include DNA methylation, histone modifications, non-coding …
sequence. Epigenetic features include DNA methylation, histone modifications, non-coding …
Pharmacological targeting of the cancer epigenome
Epigenetic dysregulation is increasingly appreciated as a hallmark of cancer, including
disease initiation, maintenance and therapy resistance. As a result, there have been …
disease initiation, maintenance and therapy resistance. As a result, there have been …