The chemical biology of ferroptosis in the central nervous system

RR Ratan - Cell chemical biology, 2020 - cell.com
Over the past five decades, thanatology has come to include the study of how individual
cells in our bodies die appropriately and inappropriately in response to physiological and …

Emerging mechanisms and disease implications of ferroptosis: potential applications of natural products

C Ge, S Zhang, H Mu, S Zheng, Z Tan… - Frontiers in Cell and …, 2022 - frontiersin.org
Ferroptosis, a newly discovered form of regulatory cell death (RCD), has been demonstrated
to be distinct from other types of RCD, such as apoptosis, necroptosis, and autophagy …

[HTML][HTML] Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease

BR Stockwell, JPF Angeli, H Bayir, AI Bush, M Conrad… - Cell, 2017 - cell.com
Ferroptosis is a form of regulated cell death characterized by the iron-dependent
accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that …

[HTML][HTML] Ferroptosis: A flexible constellation of related biochemical mechanisms

SJ Dixon, DA Pratt - Molecular cell, 2023 - cell.com
It is common to think about and depict biological processes as being governed by fixed
pathways with specific components interconnected by concrete positive and negative …

Ferroptosis and its role in diverse brain diseases

A Weiland, Y Wang, W Wu, X Lan, X Han, Q Li… - Molecular …, 2019 - Springer
Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is
characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads …

Ferroptosis and brain injury

L Magtanong, SJ Dixon - Developmental neuroscience, 2019 - karger.com
Ferroptosis is a nonapoptotic form of cell death characterized by the iron-dependent
accumulation of toxic lipid reactive oxygen species. Small-molecule screening and …

Mechanisms of ferroptosis and emerging links to the pathology of neurodegenerative diseases

Y Sun, X Xia, D Basnet, JC Zheng… - Frontiers in aging …, 2022 - frontiersin.org
Neurodegenerative diseases are a diverse class of diseases attributed to chronic
progressive neuronal degeneration and synaptic loss in the brain and/or spinal cord …

Ferroptosis: A potential therapeutic target for neurodegenerative diseases

D Vitalakumar, A Sharma… - Journal of Biochemical …, 2021 - Wiley Online Library
Ferroptosis is a newly identified regulated form of cell death, which is thought to play a major
role in neurodegenerative diseases. In this review, we discuss recent studies elucidating the …

The chemical basis of ferroptosis

M Conrad, DA Pratt - Nature chemical biology, 2019 - nature.com
Lipid peroxidation underlies the mechanism of oxidative cell death now known as
ferroptosis. This modality, distinct from other forms of cell death, has been intensely …

Ferroptosis and its potential as a therapeutic target

H Yuan, J Pratte, C Giardina - Biochemical pharmacology, 2021 - Elsevier
Ferroptosis is a recently defined form of programmed cell death that is different from
apoptosis. It is an iron-dependent programmed cell death and the accumulation of lipid …