The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells
(hPSCs) is a major goal for regenerative medicine. During embryonic development, HSCs …

The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells
(hPSCs) will depend on the accurate recapitulation of embryonic haematopoiesis. In the …

Hematopoietic stem cells (HSCs) develop from a specialized subpopulation of endothelial
cells known as hemogenic endothelium (HE). Although the HE origin of HSCs is now well …

Hemogenic endothelium (HE) has been recognized as a source of hematopoietic stem cells
(HSCs) in the embryo. Access to human HE progenitors (HEPs) is essential for enabling the …

The developmental origin of blood-forming hematopoietic stem cells (HSCs) is a
longstanding question. Here, our non-invasive genetic lineage tracing in mouse embryos …

The ability to generate hematopoietic stem cells from human pluripotent cells would enable
many biomedical applications. We find that hematopoietic CD34+ cells in spin embryoid …

In vitro generation of hematopoietic cells and especially hematopoietic stem cells (HSCs)
from human pluripotent stem cells (PSCs) are subject to intensive research in recent …

A variety of tissue lineages can be differentiated from pluripotent stem cells by mimicking
embryonic development through stepwise exposure to morphogens, or by conversion of one …

Hematopoietic stem cells (HSCs) are self-renewing, tissue-specific stem cells that give rise
to all mature blood cell types. The capacity of HSCs to reconstitute the entire adult …

NOTCH signaling is required for the arterial specification and formation of hematopoietic
stem cells (HSCs) and lympho-myeloid progenitors in the embryonic aorta-gonad …