Transcriptomics for radiation biodosimetry: progress and challenges

SA Amundson - International journal of radiation biology, 2023 - Taylor & Francis
Purpose Transcriptomic-based approaches are being developed to meet the needs for large-
scale radiation dose and injury assessment and provide population triage following a …

New approaches for quantitative reconstruction of radiation dose in human blood cells

SA Ghandhi, I Shuryak, SR Morton, SA Amundson… - Scientific Reports, 2019 - nature.com
In the event of a nuclear attack or large-scale radiation event, there would be an urgent need
for assessing the dose to which hundreds or thousands of individuals were exposed …

Development of gene expression signatures for practical radiation biodosimetry

S Paul, SA Amundson - … Journal of Radiation Oncology* Biology* Physics, 2008 - Elsevier
PURPOSE: In a large-scale radiologic emergency, estimates of exposure doses and
radiation injury would be required for individuals without physical dosimeters. Current …

Radiation-induced alternative transcription and splicing events and their applicability to practical biodosimetry

E Macaeva, Y Saeys, K Tabury, A Janssen… - Scientific reports, 2016 - nature.com
Accurate assessment of the individual exposure dose based on easily accessible samples
(eg blood) immediately following a radiological accident is crucial. We aimed at developing …

Current status, new frontiers and challenges in radiation biodosimetry using cytogenetic, transcriptomic and proteomic technologies

M Fenech - Radiation Measurements, 2011 - Elsevier
Biodosimetric methods for determining exposure dose in individuals following a radiation
accident are important for the health management of the exposed cohort and prioritisation of …

[HTML][HTML] Biomarkers for biodosimetry and their role in predicting radiation injury

M Aryankalayil, MA Bylicky, S Chopra, J Dalo… - … and genome research, 2023 - karger.com
Radiation-related normal tissue injury sustained during cancer radiotherapy or in a
radiological or mass casualty nuclear incident is a major health concern. Reducing the risk …

Developing gender-specific gene expression biodosimetry using a panel of radiation-responsive genes for determining radiation dose in human peripheral blood

S Li, X Lu, JB Feng, M Tian, J Wang… - Radiation …, 2019 - meridian.allenpress.com
In a large-scale radiological incident, rapid and high-throughput biodosimetry would be
needed. Gene expression-based biodosimetry is a promising approach to determine the …

Gene expression analysis in radiotherapy patients and C57BL/6 mice as a measure of exposure to ionizing radiation

AN Filiano, HM Fathallah-Shaykh… - Radiation …, 2011 - meridian.allenpress.com
Dose assessment after radiological disasters is imperative to decrease mortality through
rationally directed medical intervention. Our goal was to identify biomarkers capable of …

Radiation dose-rate effects on gene expression in a mouse biodosimetry model

S Paul, LB Smilenov, CD Elliston… - Radiation …, 2015 - meridian.allenpress.com
In the event of a nuclear accident or radiological terrorist attack, there will be a pressing
need for biodosimetry to triage a large, potentially exposed population and to assign …

Rapid high-throughput diagnostic triage after a mass radiation exposure event using early gene expression changes

M Port, P Ostheim, M Majewski, T Voss… - Radiation …, 2019 - meridian.allenpress.com
Radiological exposure scenarios involving large numbers of people require a rapid and
high-throughput method to identify the unexposed, and those exposed to low-and high-dose …