Wnt signaling affects fundamental development pathways and, if aberrantly activated,
promotes the development of cancers. Wnt signaling is modulated by different factors, but …

Mitochondria serve a critical role in physiology and disease. The genetic basis of
mitochondrial regulation in mammalian cells has not yet been detailed. We performed a …

The regulation of mitochondrial dynamics is vital in complex cell types, such as neurons, that
transport and localize mitochondria in high energy-demanding cell domains. The Armcx3 …

Cancer cells are known to upregulate aerobic glycolysis to promote growth, proliferation,
and survival. However, the role of mitochondrial respiration in tumorigenesis remains …

Alzheimer's disease (AD) is the most common neurodegenerative disorder and is
characterized by progressive memory loss and cognitive decline. One of the hallmarks of AD …

Emerging evidence suggests that reactive oxygen species (ROS) can stimulate the Wnt/β-
catenin pathway in a number of cellular processes. However, potential sources of …

Wnt signaling plays a critical role in embryonic development, and its deregulation is closely
linked to the occurrence of a number of malignant tumors, including breast and colon …

Mitochondrial abundance is dynamically regulated and was previously shown to be
increased by Wnt/β-catenin signaling. Pgam5 is a mitochondrial phosphatase which is …

Cancer cells are known for their ability to adapt variable metabolic programs depending on
the availability of specific nutrients. Our previous studies have shown that uptake of fatty …

The mitochondrial unfolded protein response (UPR mt) can be triggered in a cell-non-
autonomous fashion across multiple tissues in response to mitochondrial dysfunction. The …