Concentric pulmonary vascular wall thickening due partially to increased pulmonary artery
(PA) smooth muscle cell (PASMC) proliferation contributes to elevating pulmonary vascular …

Emerging studies have reported the mechanosensitive Piezo1 (piezo type
mechanosensitive ion channel component 1) plays essential roles in regulating the vascular …

Mechanical forces are translated into biochemical stimuli by mechanotransduction channels,
such as the mechanically activated cation channel Piezo2. Lung Piezo2 expression has …

Introduction Piezo1 is an important mechanosensitive channel implicated in vascular
remodeling. However, the role of Piezo1 in different types of vascular cells during the …

Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca2+ and Na+
influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung …

In intrapulmonary arteries (IPAs), mechanical forces due to blood flow control vessel tone,
and these forces change during pulmonary hypertension (PH). Piezo1, a stretch-activated …

In intrapulmonary arteries (IPA), endothelial cells (EC) respond to mechanical stimuli by
releasing vasoactive factors to set the vascular tone. Piezo1, a stretch-activated, calcium …

Piezo channels are deemed to constitute one of the most important family of
mechanosensing ion channels since their discovery in 2010. With recent advances in …

Pulmonary vasoconstriction and vascular medial hypertrophy greatly contribute to the
elevated pulmonary vascular resistance in patients with pulmonary hypertension. A rise in …

An increase in cytosolic Ca2+ concentration ([Ca2+] cyt) in pulmonary arterial smooth
muscle cells (PASMC) is a major trigger for pulmonary vasoconstriction and an important …