Neurological conditions such as traumatic brain injury, stroke, Parkinson's disease, epilepsy,
multiple sclerosis, and Alzheimer's disease are serious clinical problems that affect millions …

Due to the extension of human life expectancy, the prevalence of cognitive impairment is
rising in the older portion of society. Developing new strategies to delay or attenuate …

Research toward the development and use of animals models of age-related
neurodegeneration and memory loss has accelerated rapidly during the past decade …

We all know that age-related neurodegenerative diseases affect aging individuals. So why
does basic research continue to make use of the immature nervous system or mutants that …

A major obstacle to progress in understanding the etiology of normative and pathological
human brain aging is the availability of suitable animal models for experimentation. The …

In the past, structural changes in the brain with aging have been studied using a variety of
animal models, with rats and nonhuman primates being the most popular. With the rapid …

Recognition that aging is not the accumulation of disease, but rather comprises fundamental
biological processes that are amenable to experimental study, is the basis for the recent …

Increased interest is emerging for using mouse models to assess the genetics of brain aging
and age-related neurodegenerative diseases. Despite this demand, relatively little …

Age is the only one non-modifiable risk of cerebral ischemia. Advances in stroke medicine
and behavioral adaptation to stroke risk factors and comorbidities was successful in …

Substantial resources and effort have been invested into the development of therapeutic
agents for Alzheimer's disease (AD) with mixed and limited success. Research into the …