The localization of substance P (SP) binding sites in guinea-pig heart was studied by in vitro
autoradiography, and pharmacological effects of SP were examined with isolated heart …

The cardiovascular effects of Substance P (SP) administered into the cisterna magna (ic) of
the pentobarbitone anaesthetised rabbit have been investigated. SP given ic in low doses …

The cardiovascular effects of CP-96,345, a non-peptide antagonist of substance P, were
analyzed in vivo and in vitro. In the anaesthetized rat, the iv injection of 3 µmolkg− 1 of CP …

The neuropeptide and putative neurotransmitter, substance P, has been found in peripheral
nerves and in regions of the autonomic nervous system which may participate in …

Magnesium (Mg)-deficiency, whether dietary or an effect of a clinical condition such as
diabetes, results in a variety of cardiovascular pathologies. Substance P (SP) has been …

Negative chronotropic and vasodilator responses of the isolated perfused guinea pig heart
to substance P (SP) were evaluated. Bolus injections of 2.5, 25 and 125 nmol of SP caused …

The local cardiac actions of substance P were examined in isolated perfused hearts and
atria of the guinea-pig. 2. In both hearts and right atria, substance P caused negative …

1. Substance P, injected into a lateral brain ventricle of urethane-anaesthetized rats, caused
dose-dependent increases in blood pressure and heart rate. 2. By contrast, exposure of the …

We report the presence of substance P-like immunoreactivity in the guinea-pig heart and its
localisation in varicose nerve fibres distributed throughout this organ. Immunoreactive fibres …

Regional distribution of endogenous substance P and the specific [3 H] substance P binding
to synaptic membranes in rabbit central nervous system were investigated. The highest level …