Under normal conditions, cells of almost all tissue types express the same predominant
canonical transcript isoform at each gene locus. In cancer, however, splicing regulation is …

Alternative usage of transcript isoforms from the same gene has been hypothesized as an
important feature in cancers. However, differential usage of gene transcripts between …

The determination of the alternative splicing isoforms expressed in cancer is fundamental for
the development of tumor-specific molecular targets for prognosis and therapy, but it is …

Background Alternative splicing provides a major mechanism to generate protein diversity.
Increasing evidence suggests a link of dysregulation of splicing associated with cancer …

Background We have previously proposed transcriptome instability as a genome-wide, pre-
mRNA splicing-related characteristic of colorectal cancer. Here, we explore the hypothesis …

Most cancer driver genes are involved in generic cellular processes such as DNA repair, cell
proliferation and cell adhesion, yet their mutations are often confined to specific cancer …

It is increasingly appreciated that alternative splicing plays a key role in generating
functional specificity and diversity in cancer. However, the mechanisms by which cancer …

Alternative splicing changes are frequently observed in cancer and are starting to be
recognized as important signatures for tumor progression and therapy. However, their …

Background Dysregulation of alternative splicing (AS) is a critical signature of cancer.
However, the regulatory mechanisms of cancer-specific AS events, especially the impact of …

Alternative splicing is regulated by multiple RNA-binding proteins and influences the
expression of most eukaryotic genes. However, the role of this process in human disease …