Pathogenic impact of transcript isoform switching in 1,209 cancer samples covering 27 cancer types using an isoform-specific interaction network
Under normal conditions, cells of almost all tissue types express the same predominant
canonical transcript isoform at each gene locus. In cancer, however, splicing regulation is …
canonical transcript isoform at each gene locus. In cancer, however, splicing regulation is …
The landscape of isoform switches in human cancers
K Vitting-Seerup, A Sandelin - Molecular Cancer Research, 2017 - AACR
Alternative usage of transcript isoforms from the same gene has been hypothesized as an
important feature in cancers. However, differential usage of gene transcripts between …
important feature in cancers. However, differential usage of gene transcripts between …
Detection of recurrent alternative splicing switches in tumor samples reveals novel signatures of cancer
E Sebestyén, M Zawisza, E Eyras - Nucleic acids research, 2015 - academic.oup.com
The determination of the alternative splicing isoforms expressed in cancer is fundamental for
the development of tumor-specific molecular targets for prognosis and therapy, but it is …
the development of tumor-specific molecular targets for prognosis and therapy, but it is …
Identification of mRNA isoform switching in breast cancer
Background Alternative splicing provides a major mechanism to generate protein diversity.
Increasing evidence suggests a link of dysregulation of splicing associated with cancer …
Increasing evidence suggests a link of dysregulation of splicing associated with cancer …
Transcriptome instability as a molecular pan-cancer characteristic of carcinomas
A Sveen, B Johannessen, MR Teixeira, RA Lothe… - BMC genomics, 2014 - Springer
Background We have previously proposed transcriptome instability as a genome-wide, pre-
mRNA splicing-related characteristic of colorectal cancer. Here, we explore the hypothesis …
mRNA splicing-related characteristic of colorectal cancer. Here, we explore the hypothesis …
Explaining cancer type specific mutations with transcriptomic and epigenomic features in normal tissues
KL Tiong, CH Yeang - Scientific Reports, 2018 - nature.com
Most cancer driver genes are involved in generic cellular processes such as DNA repair, cell
proliferation and cell adhesion, yet their mutations are often confined to specific cancer …
proliferation and cell adhesion, yet their mutations are often confined to specific cancer …
Revealing the determinants of widespread alternative splicing perturbation in cancer
It is increasingly appreciated that alternative splicing plays a key role in generating
functional specificity and diversity in cancer. However, the mechanisms by which cancer …
functional specificity and diversity in cancer. However, the mechanisms by which cancer …
The functional impact of alternative splicing in cancer
Alternative splicing changes are frequently observed in cancer and are starting to be
recognized as important signatures for tumor progression and therapy. However, their …
recognized as important signatures for tumor progression and therapy. However, their …
Genome-wide analysis reveals the association between alternative splicing and DNA methylation across human solid tumors
Background Dysregulation of alternative splicing (AS) is a critical signature of cancer.
However, the regulatory mechanisms of cancer-specific AS events, especially the impact of …
However, the regulatory mechanisms of cancer-specific AS events, especially the impact of …
Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks
Alternative splicing is regulated by multiple RNA-binding proteins and influences the
expression of most eukaryotic genes. However, the role of this process in human disease …
expression of most eukaryotic genes. However, the role of this process in human disease …
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