Cell suspension culture extract of Eriobotrya japonica attenuates growth and induces apoptosis in prostate cancer cells via targeting SREBP-1/FASN-driven …

PF Hsieh, WP Jiang, P Basavaraj, SY Huang… - Phytomedicine, 2021 - Elsevier
Background Castration-resistant prostate cancer (CRPC) is one of the main causes of male
cancer mortality. There is currently no effective treatment to cure this deadly prostate cancer …

[HTML][HTML] Eriocalyxin B induces apoptosis and autophagy involving Akt/mammalian target of rapamycin (mTOR) pathway in prostate cancer cells

Z Yu, Y Chen, C Liang - Medical Science Monitor: International …, 2019 - ncbi.nlm.nih.gov
Background Eriocalyxin B (EriB), a diterpenoid isolated from the plant Isodon eriocalyx, has
been shown to possess anti-tumor properties. However, few systematic studies of the …

Ethanol Extract of Evodia rutaecarpa Attenuates Cell Growth through Caspase-Dependent Apoptosis in Benign Prostatic Hyperplasia-1 Cells

E Park, MY Lee, CS Seo, JH Jang, Y Kim, HK Shin - Nutrients, 2018 - mdpi.com
The dried fruits of Evodia rutaecarpa Bentham have been used widely as a herbal medicine
for the treatment of inflammatory disorders and abdominal pain. Benign prostatic …

Ganoderma tsugae Inhibits the SREBP-1/AR Axis Leading to Suppression of Cell Growth and Activation of Apoptosis in Prostate Cancer Cells

SY Huang, GJ Huang, HC Wu, MC Kao, WC Huang - Molecules, 2018 - mdpi.com
Recent research suggests that the activation of lipid biosynthesis (lipogenesis) is linked with
prostate cancer (PCa) malignancy. Sterol regulatory element-binding protein-1 (SREBP-1) is …

Ericifolin: a novel antitumor compound from allspice that silences androgen receptor in prostate cancer

N Shamaladevi, DA Lyn, KA Shaaban, L Zhang… - …, 2013 - academic.oup.com
Silencing of androgen receptor (AR) signaling is a specific and effective mechanism to cure
cancer of the prostate (CaP). In this study, the isolation and characterization of a compound …

Alpinumisoflavone exhibits the therapeutic effect on prostate cancer cells by repressing AR and co-targeting FASN-and HMGCR-mediated lipid and cholesterol …

P Basavaraj, P Ruangsai, PF Hsieh, WP Jiang, DT Bau… - Life, 2022 - mdpi.com
Prostate cancer (PCa) is the most common cancer in men, and this has been mainly noticed
in Western and Asian countries. The aggregations of PCa and castration-resistant PCa …

Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK …

B Ma, H Zhang, Y Wang, A Zhao, Z Zhu, X Bao… - Journal of Experimental …, 2018 - Springer
Background The development of potent non-toxic chemotherapeutic drugs against
castration resistant prostate cancer (CRPC) remains a major challenge. Corosolic acid (CA) …

[HTML][HTML] Investigating the synergy of Shikonin and Valproic acid in inducing apoptosis of osteosarcoma cells via ROS-mediated EGR1 expression

Z Chen, F Wu, J Li, J Dong, H He, X Li, Q Lu, W Zhang… - Phytomedicine, 2024 - Elsevier
Background Osteosarcoma is the most prevalent malignant bone tumour with a poor
prognosis. Shikonin (SHK) is derived from the traditional Chinese medicine Lithospermum …

Rooibos suppresses proliferation of castration-resistant prostate cancer cells via inhibition of Akt signaling

SH Huang, JC Tseng, CY Lin, YY Kuo, BJ Wang… - Phytomedicine, 2019 - Elsevier
Background Androgen ablation therapy is the primary treatment for metastatic prostate
cancer (PCa). However, the majority of PCa patients receiving the androgen deprivation …

Isodon eriocalyx and its bioactive component Eriocalyxin B enhance cytotoxic and apoptotic effects of gemcitabine in pancreatic cancer

L Li, SL Zhao, GGL Yue, TP Wong, JX Pu, HD Sun… - Phytomedicine, 2018 - Elsevier
Background Pancreatic cancer, associated with poor prognosis and low survival rate, has
been the fourth leading cause of cancer-related death in the US. Although gemcitabine …