Summary NG2-expressing glia (NG2 glia) are a uniformly distributed and mitotically active
pool of cells in the central nervous system (CNS). In addition to serving as progenitors of …

NG2 glia, also known as oligodendrocyte precursor cells (OPCs), play an important role in
proliferation and give rise to myelinating oligodendrocytes during early brain development …

NG2-expressing neural progenitor cells (ie, NG2 glial cells) maintain their proliferative and
migratory activities even in the adult mammalian central nervous system (CNS) and produce …

Adult neurogenesis in the dentate gyrus of the hippocampus is regulated by specific
microglia groups and functionally implicated in behavioral responses to stress. However, the …

Background Brain innate immunity is vital for maintaining normal brain functions. Immune
homeostatic imbalances play pivotal roles in the pathogenesis of neurological diseases …

The link between the onset of major depressive disorder (MDD) and loss of neurotrophins in
the brain is of interest to clinicians and basic scientists. MDD is caused by a combination of …

Recent studies have suggested that cortical astroglia play an important role in depressive-
like behaviors. Potential astroglial contributions have been proposed based on their known …

Despite intense ongoing research efforts, the etiology of psychiatric disorders remains
incompletely understood. Among biological factors playing a role in Major Depressive …

Although multiple studies have reported that peripheral glial cell line-derived neurotrophic
factor (GDNF) is reduced in depression, cerebral GDNF signalling has yet to be examined in …

Basic and clinical studies demonstrate that stress and depression are associated with
atrophy and loss of neurons and glia, which contribute to the decreased size and function of …