Polysaccharides derived from Chinese medicinal herbs: A promising choice of vaccine adjuvants

X Wan, Y Yin, C Zhou, L Hou, Q Cui, X Zhang… - Carbohydrate …, 2022 - Elsevier
Adjuvants have been used in vaccines for a long time to promote the body's immune
response, reducing vaccine dosage and production costs. Although many vaccine adjuvants …

Polysaccharides: Candidates of promising vaccine adjuvants

P Li, F Wang - Drug discoveries & therapeutics, 2015 - jstage.jst.go.jp
Aluminium-based adjuvants remain the only adjuvants approved for human use in the USA
for over 80 years because of alum's simplicity, tolerability, safety and cost-efficiency. Recent …

The adjuvant effects on vaccine and the immunomodulatory mechanisms of polysaccharides from traditional Chinese medicine

D Wang, Y Liu, W Zhao - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Vaccination is still the most successful strategy to prevent and control the spread of
infectious diseases by generating an adequate protective immune response. However …

Polysaccharides as vaccine adjuvants

B Sun, S Yu, D Zhao, S Guo, X Wang, K Zhao - Vaccine, 2018 - Elsevier
Adjuvant is a substance added to vaccine to improve the immunogenicity of antigens, and it
can induce stronger immune responses and reduce the dosage and production cost of …

Bioactive polysaccharides from traditional Chinese medicine herbs as anticancer adjuvants

R Chang - The Journal of Alternative & Complementary Medicine, 2002 - liebertpub.com
Purpose of study: To review the nature, extent, bioactivities, and clinical application of
polysaccharides in Traditional Chinese Medicine (TCM) especially as adjuvants in cancer …

Sulfated modification can enhance the adjuvant activity of astragalus polysaccharide for ND vaccine

X Huang, Y Hu, X Zhao, Y Lu, J Wang, F Zhang… - Carbohydrate …, 2008 - Elsevier
Two hundred 14-day-old chickens were divided randomly into 10 groups. At the same time
of vaccination with Newcastle disease vaccine, the chickens in six experimental groups …

Novel polysaccharide adjuvant from the roots of Actinidia eriantha with dual Th1 and Th2 potentiating activity

HX Sun, H Wang, H Xu, Y Ni - Vaccine, 2009 - Elsevier
The plant polysaccharides are recognized as an effective biological response modifier with
low toxicity. In this study, the water-soluble polysaccharide from the roots of Actinidia …

Structural characterization and immune activity screening of polysaccharides with different molecular weights from Astragali Radix

K Li, YX Cao, SM Jiao, GH Du, YG Du… - Frontiers in …, 2020 - frontiersin.org
Saccharides are the most abundant substance with the strongest immunological activity in
Astragali Radix (AR). However, systematic structure study and immunoactivity screening of …

Evaluation of widely consumed botanicals as immunological adjuvants

G Ragupathi, KS Yeung, PC Leung, M Lee… - Vaccine, 2008 - Elsevier
BACKGROUND: Many widely used botanical medicines are claimed to be immune
enhancers. Clear evidence of augmentation of immune responses in vivo is lacking in most …

Adjuvant activities of saponins from traditional Chinese medicinal herbs

X Song, S Hu - Vaccine, 2009 - Elsevier
New generation vaccines such as recombinant, antigen purified and DNA vaccines are
poorly immunogenic due to the lack of an innate immune stimulus. Therefore, search of new …