Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1* 0101), complexed with the immunodominant determinant of human …
EF Rosloniec, RA Ivey, KB Whittington… - The Journal of …, 2006 - journals.aai.org
The expression of HLA-DR1 (DRB1* 0101) is associated with an enhanced risk for
developing rheumatoid arthritis (RA). To study its function, we have solved the three …
developing rheumatoid arthritis (RA). To study its function, we have solved the three …
[HTML][HTML] X-ray crystal structure of HLA-DR4 (DRA* 0101, DRB1* 0401) complexed with a peptide from human collagen II
A Dessen, CM Lawrence, S Cupo, DM Zaller, DC Wiley - Immunity, 1997 - cell.com
Genetic predisposition to rheumatoid arthritis (RA) is linked to the MHC class II allele HLA-
DR4. The charge of the amino acid at DRβ71 in the peptide-binding site appears to be …
DR4. The charge of the amino acid at DRβ71 in the peptide-binding site appears to be …
HLA-DR1 (DRB1* 0101) and DR4 (DRB1* 0401) use the same anchor residues for binding an immunodominant peptide derived from human type II collagen
EF Rosloniec, KB Whittington, DM Zaller… - The Journal of …, 2002 - journals.aai.org
Rheumatoid arthritis is an autoimmune disease in which susceptibility is strongly associated
with the expression of specific HLA-DR haplotypes, including DR1 (DRB1* 0101) and DR4 …
with the expression of specific HLA-DR haplotypes, including DR1 (DRB1* 0101) and DR4 …
Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis …
EC Andersson, BE Hansen… - Proceedings of the …, 1998 - National Acad Sciences
Rheumatoid arthritis (RA) is an autoimmune disease associated with the HLA-DR4 and DR1
alleles. The target autoantigen (s) in RA is unknown, but type II collagen (CII) is a candidate …
alleles. The target autoantigen (s) in RA is unknown, but type II collagen (CII) is a candidate …
A structural model for TCR recognition of the HLA class II shared epitope sequence implicated in susceptibility to rheumatoid arthritis
JE Penzotti, D Doherty, TP Lybrand, GT Nepom - Journal of autoimmunity, 1996 - Elsevier
HLA molecules associated with rheumatoid arthritis (RA) contain a discrete structural
element known as the shared epitope, a set of conserved amino acid residues located on …
element known as the shared epitope, a set of conserved amino acid residues located on …
Human collagen II peptide 256–271 preferentially binds to HLA-DR molecules associated with susceptibility to rheumatoid arthritis
BY Diab, NC Lambert, FE L'Faqihi, P Loubet-Lescoulié… - Immunogenetics, 1999 - Springer
The binding ability of 23 overlapping peptides, all derived from the CB11 fragment of CII,
was tested on several HLA-DR molecules associated or not with disease susceptibility …
was tested on several HLA-DR molecules associated or not with disease susceptibility …
The influence of HLA-DR4 (0401) on the immune response to type II collagen and the development of collagen induced arthritis in mice
D Wang, JA Hill, E Cairns, DA Bell - Journal of autoimmunity, 2002 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune disease that is genetically associated with the
MHC class II molecule HLA-DRβ1* 0401 (DR4). In order to determine if this MHC can …
MHC class II molecule HLA-DRβ1* 0401 (DR4). In order to determine if this MHC can …
Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1* 04: 01 molecule, the major glycosylated collagen II peptide and …
C Ge, S Weisse, B Xu, D Dobritzsch… - Annals of the …, 2022 - ard.bmj.com
Objectives Rheumatoid arthritis (RA) is an autoimmune disease strongly associated with the
major histocompatibility complex (MHC) class II allele DRB1* 04: 01, which encodes a …
major histocompatibility complex (MHC) class II allele DRB1* 04: 01, which encodes a …
Collagen-induced arthritis mediated by HLA-DR1 (* 0101) and HLA-DR4 (* 0401)
EF Rosloniec, KB Whittington, AH Kang… - The American journal of …, 2004 - Elsevier
Although associations between the expression of particular HLA genes and susceptibility to
specific autoimmune diseases has been known for some time, the role HLA molecules play …
specific autoimmune diseases has been known for some time, the role HLA molecules play …
The relationship between predicted peptide–MHC class II affinity and T-cell activation in a HLA-DRβ1* 0401 transgenic mouse model
JA Hill, D Wang, AM Jevnikar, E Cairns, DA Bell - Arthritis Res Ther, 2002 - Springer
Abstract The HLA-DRB1* 0401 MHC class II molecule (DR4) is genetically associated with
rheumatoid arthritis. It has been proposed that this MHC class II molecule participates in …
rheumatoid arthritis. It has been proposed that this MHC class II molecule participates in …
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