Glutamate levels of the right and left anterior cingulate cortex in autistics adults

F Briend, L Barantin, H Cléry, JP Cottier… - Progress in Neuro …, 2023 - Elsevier
Abstract Background The neurobiology of Autism Spectrum Disorder (ASD) is still unknown.
Alteration in glutamate metabolism might translate into an imbalance of the …

[HTML][HTML] Disturbed cingulate glutamate metabolism in adults with high-functioning autism spectrum disorder: evidence in support of the excitatory/inhibitory imbalance …

L Tebartz van Elst, S Maier, T Fangmeier… - Molecular …, 2014 - nature.com
Over the last few years, awareness of autism spectrum disorder (ASD) in adults has
increased. The precise etiology of ASD is still unresolved. Animal research, genetic and …

[HTML][HTML] Reduced subcortical glutamate/glutamine in adults with autism spectrum disorders: a [1H] MRS study

J Horder, T Lavender, MA Mendez, R O'gorman… - Translational …, 2013 - nature.com
Dysfunctional glutamatergic neurotransmission has been implicated in autism spectrum
disorder (ASD). However, relatively few studies have directly measured brain glutamate in …

Increased prefrontal GABA concentrations in adults with autism spectrum disorders

S Maier, AL Düppers, K Runge, M Dacko… - Autism …, 2022 - Wiley Online Library
The excitatory‐inhibitory imbalance hypothesis postulates dysregulation of the gamma‐
aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems as a common …

Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: a pilot study at 4T

G Joshi, J Biederman, J Wozniak, RL Goldin… - European archives of …, 2013 - Springer
The pilot study aimed at examining the neural glutamatergic activity in autism. Seven
adolescent males (mean age: 14±1.8; age range: 12–17 years) with intact intellectual …

Biochemistry of the cingulate cortex in autism: An MR spectroscopy study

LE Libero, MA Reid, DM White, N Salibi… - Autism …, 2016 - Wiley Online Library
Neuroimaging studies have uncovered structural and functional alterations in the cingulate
cortex in individuals with autism spectrum disorders (ASD). Such abnormalities may underlie …

[HTML][HTML] Elevated Glutamatergic Compounds in Pregenual Anterior Cingulate in Pediatric Autism Spectrum Disorder Demonstrated by 1H MRS and 1H MRSI

A Bejjani, J O'Neill, JA Kim, AJ Frew, VW Yee, R Ly… - 2012 - journals.plos.org
Recent research in autism spectrum disorder (ASD) has aroused interest in anterior
cingulate cortex and in the neurometabolite glutamate. We report two studies of pregenual …

[HTML][HTML] Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism

M Oya, K Matsuoka, M Kubota, J Fujino, S Tei… - Scientific Reports, 2023 - nature.com
Increased excitatory neuronal tones have been implicated in autism, but its mechanism
remains elusive. The amplified glutamate signals may arise from enhanced glutamatergic …

Relationship among glutamine, γ-aminobutyric acid, and social cognition in autism spectrum disorders

DM Cochran, EM Sikoglu, SM Hodge… - Journal of child and …, 2015 - liebertpub.com
Objective: An imbalance of excitatory and inhibitory neurotransmission in autism spectrum
disorder (ASD) has been proposed. We compared glutamate (Glu), glutamine (Gln), and γ …

Medial Frontal Lobe Neurochemistry in Autism Spectrum Disorder is Marked by Reduced N-Acetylaspartate and Unchanged Gamma-Aminobutyric Acid and …

A Carvalho Pereira, IR Violante, S Mouga… - Journal of Autism and …, 2018 - Springer
The nature of neurochemical changes in autism spectrum disorder (ASD) remains
controversial. We compared medial prefrontal cortex (mPFC) neurochemistry of twenty high …