Many autoimmune disorders such as psoriasis lead to the alteration of skin components
which generally manifests as unwanted topical symptoms. One of the most widely approved …

Since 2009, the imiquimod-or Aldara-induced (3M Pharmaceuticals, St. Paul, MN) model of
acute skin inflammation has become the most widely used mouse model in preclinical …

Imiquimod (IMQ)-induced skin inflammation is currently the most widely accepted psoriasis
animal model, however, it features several limitations. We have modified the IMQ-model to …

Psoriasis is a chronic inflammatory skin disease of unknown etiology. Previous studies
showed that short-term, 5–7 d-long application of imiquimod (IMQ), a TLR7 agonist, to the …

Introduction: Psoriasis is an autoimmune skin disease characterized by red plaques with
silver or white multilayered scales with a thickened acanthotic epidermis. Using mouse …

Psoriasis is considered to be a systemic disease of immune dysfunction. It is still unclear
what triggers the inflammatory cascade associated with psoriasis but recent evidences …

The use of preclinical animal models of psoriasis has significantly increased over the last
three decades, with each model having unique strengths and limitations. Some models …

Psoriasis is a chronic inflammatory skin disease that is thought to be related to oxidative
stress. Much progress has been made in understanding the pathophysiology of psoriasis in …

Psoriasis is an inflammatory disease of the skin affecting 2–3% of the population,
characterized by a thickening of the epidermis and immune infiltrates throughout the dermis …

Background Imiquimod (IMQ) produces a cutaneous phenotype in mice frequently studied
as an acute model of human psoriasis. Whether this phenotype depends on strain or sex …