Study Design. Laboratory study. Objective. The aims of this study were as follows:(1) to
confirm that Substance P (SP) is expressed by nucleus pulposus (NP) and annulus fibrosus …

Study Design. Laboratory study. Objective. Evaluate the effect of substance P (SP) on an
intervertebral disc rat organ culture model. Summary of Background Data. Monolayer cell …

Objective. To evaluate whether blockade of the Substance P (SP) NK1R attenuates its
proinflammatory effect on human intervertebral disc cells (IVD), and to evaluate the signaling …

Inflammatory pain involves the sensitization of both primary afferent and spinal cord
neurons. To explore the neurochemical changes that contribute to inflammatory pain, we …

There is increasing evidence that local substance P (SP) exacerbates peripheral
inflammations, partly by stimulating production of inflammatory cytokines such as interleukin …

Substance P is a neuropeptide believed to be a major mediator of neurogenic inflammation.
The aim of our study was to evaluate whether substance P levels are elevated in the clinical …

Neurogenic inflammation describes the local release of neuropeptides, notably substance P
(SP), from afferent neurons and might play a role in the pathogenesis of pulpal disease. The …

Substance P (SP) is an important modulator of neuroimmunoregulation. We have
demonstrated that human T lymphocytes express SP and neurokinin-1 receptor (NK-1R), a …

Objective: Our previous study found that substance P (SP), a sensory neuropeptide, was
expressed in the dental pulp of rats during experimental tooth movement. We examined the …

Current rheumatoid arthritis (RA) therapies such as biologics inhibiting pathogenic cytokines
substantially delay RA progression. However, patient responses to these agents are not …