Hypoxia-inducible factor-1 (HIF-1) is a heterodimer transcription factor composed of an
alpha and a beta subunit. HIF-1α is a master regulator of cellular response to hypoxia by …

Objective The study aimed to establish whether HIF1α entrains the core clock in
chondrocytes and how the HIF1α affects the circadian rhythm. Methods We subjected …

HIF-1α, an essential transcription factor under hypoxic condition, is indispensable for
chondrocytes during skeletal development but its expression and roles in articular …

Hypoxia occurs not only in pathological conditions like cancer and ischemia and in a variety
of physiological settings in the adult organism, but also during normal embryonic …

Osteoarthritis (OA) is a common and debilitating joint disease which develops and
progresses with age. Despite extensive research into the disease, potent disease-modifying …

Oxygen availability is a critical signal for the proper development of many tissues. The
transcription factor hypoxia-inducible factor (HIF) plays an important role in maintenance of …

The physiologically hypoxic intervertebral disc and cartilage rely on the hypoxia-inducible
factor (HIF) family of transcription factors to mediate cellular responses to changes in oxygen …

Purpose: Hypoxia-inducible factor-1α (HIF-1α) plays a crucial role in hypoxic conditions for
cell survival in various tissues. In chondrocytes, previous studies showed that HIF-1α was …

Osteoarthritis (OA) is the most common joint disease, affecting articular cartilage of the joints,
with currently no cure. Age is a major risk factor for OA, but despite significant advances …

Osteoarthritis (OA) is the most common age-related joint disease, affecting articular cartilage
and other joint structures, causing severe pain and disability. Due to a limited understanding …