The exosome journey: from biogenesis to uptake and intracellular signalling

S Gurung, D Perocheau, L Touramanidou… - Cell Communication and …, 2021 - Springer
The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials
testing exosomes for diagnostic and therapeutic applications are generating remarkable …

Exosomes: biogenesis, biologic function and clinical potential

Y Zhang, Y Liu, H Liu, WH Tang - Cell & bioscience, 2019 - Springer
Exosomes are nano-sized biovesicles released into surrounding body fluids upon fusion of
multivesicular bodies and the plasma membrane. They were shown to carry cell-specific …

Exosomes: potential disease biomarkers and new therapeutic targets

MI Mosquera-Heredia, LC Morales, OM Vidal… - Biomedicines, 2021 - mdpi.com
Exosomes are extracellular vesicles released by cells, both constitutively and after cell
activation, and are present in different types of biological fluid. Exosomes are involved in the …

[HTML][HTML] Exosome theranostics: biology and translational medicine

C He, S Zheng, Y Luo, B Wang - Theranostics, 2018 - ncbi.nlm.nih.gov
Exosomes are common membrane-bound nanovesicles that contain diverse biomolecules,
such as lipids, proteins, and nucleic acids. Exosomes are derived from cells through …

Exosome: a new player in translational nanomedicine

H Aheget, M Tristán-Manzano, L Mazini… - Journal of Clinical …, 2020 - mdpi.com
Exosomes are extracellular vesicles released by the vast majority of cell types both in vivo
and ex vivo, upon the fusion of multivesicular bodies (MVBs) with the cellular plasma …

Challenges and opportunities in exosome research—Perspectives from biology, engineering, and cancer therapy

X Li, AL Corbett, E Taatizadeh, N Tasnim, JP Little… - APL …, 2019 - pubs.aip.org
ABSTRACT Exosomes are small ($30–140 nm) lipid bilayer-enclosed particles of
endosomal origin. They are a subset of extracellular vesicles (EVs) that are secreted by most …

Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

AV Vlassov, S Magdaleno, R Setterquist… - Biochimica et Biophysica …, 2012 - Elsevier
BACKGROUND: Cells continuously secrete a large number of microvesicles,
macromolecular complexes, and small molecules into the extracellular space. Of the …

Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes

S Gurunathan, MH Kang, M Jeyaraj, M Qasim, JH Kim - Cells, 2019 - mdpi.com
Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids,
RNA, and DNA. They are derived from endocytic membranes and can transfer signals to …

[HTML][HTML] Signaling pathways in exosomes biogenesis, secretion and fate

L Urbanelli, A Magini, S Buratta, A Brozzi, K Sagini… - Genes, 2013 - mdpi.com
Exosomes are small extracellular vesicles (30–100 nm) derived from the endosomal system,
which have raised considerable interest in the last decade. Several studies have shown that …

The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities

S Pant, H Hilton, ME Burczynski - Biochemical pharmacology, 2012 - Elsevier
Exosomes are bioactive vesicles derived from the cell's endosomal membrane system and
secreted into surrounding body fluids. Exosomes contain cell and cell-state specific cargos …