The heart is the first organ to form during development in vertebrates, and many organs start
to develop adjacent to the cardiovascular system. Endothelial cells (ECs) form the inner cell …

Reciprocal signalling between the endothelium and the pancreatic epithelium is crucial for
coordinated differentiation of the embryonic endocrine and exocrine pancreas. In the adult …

Pancreatic islets are highly vascularized mini-organs, and vascular endothelial growth factor
(VEGF)-A is a critical factor in the development of islet vascularization. To investigate the …

VEGF-A expression in beta cells is critical for pancreatic development, formation of islet-
specific vasculature, and Insulin secretion. However, two key questions remain. First, is …

In most organs, blood vessels provide a continuous supply of oxygen, nutrients, and growth
factors. In the case of pancreas, such environmental signals are crucial for both the …

Endothelial cells (ECs) are essential for pancreas differentiation, endocrine specification,
and endocrine function. They are also involved in the physiopathology of type 1 and type 2 …

Aims/hypothesis Vascular endothelial growth factor (VEGF) has been recognised by loss-of-
function experiments as a pleiotropic factor with importance in embryonic pancreas …

The vertebrate pancreas is comprised of a highly branched tubular epithelium, which is
intimately associated with an extensive and specialized vasculature. While we know a great …

Blood vessels form a highly branched, interconnected, and largely stereotyped network of
tubes that sustains every organ and tissue in vertebrates. How vessels come to take on their …

Blood vessel endothelium has been recently shown to induce endocrine pancreatic
development [1]. Because pancreatic endocrine cells or islets express high levels of …