Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiology

M Volkov, KA van Schie… - Immunological …, 2020 - Wiley Online Library
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. In
the last few decades, new insights into RA‐specific autoantibodies and B cells have greatly …

From risk to chronicity: evolution of autoreactive B cell and antibody responses in rheumatoid arthritis

HU Scherer, D van der Woude… - Nature Reviews …, 2022 - nature.com
The presence of disease-specific autoantibody responses and the efficacy of B cell-targeting
therapies in rheumatoid arthritis (RA) indicate a pivotal role for B cells in disease …

The B cell response to citrullinated antigens in the development of rheumatoid arthritis

HU Scherer, TWJ Huizinga, G Krönke… - Nature Reviews …, 2018 - nature.com
The immune response to citrullinated antigens is found almost exclusively in patients with
rheumatoid arthritis (RA). It is a dynamic response that expands before the onset of disease …

The role of autoantibodies in the pathophysiology of rheumatoid arthritis

V Derksen, TWJ Huizinga… - Seminars in …, 2017 - Springer
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation.
The presence of autoantibodies in the sera of RA patients has provided many clues to the …

Beyond citrullination: other post-translational protein modifications in rheumatoid arthritis

LA Trouw, T Rispens, REM Toes - Nature Reviews Rheumatology, 2017 - nature.com
The presence of autoantibodies is one of the hallmarks of rheumatoid arthritis (RA). In the
past few decades, rheumatoid factors (autoantibodies that recognize the Fc-tail of …

Autoantibodies in rheumatoid arthritis: historical background and novel findings

MV Sokolova, G Schett, U Steffen - Clinical reviews in allergy & …, 2022 - Springer
Autoantibodies represent a hallmark of rheumatoid arthritis (RA), with the rheumatoid factor
(RF) and antibodies against citrullinated proteins (ACPA) being the most acknowledged …

B cells in rheumatoid arthritis

S Bugatti, V Codullo, R Caporali, C Montecucco - Autoimmunity reviews, 2007 - Elsevier
Though its etiology remains unknown thus far, the role that autoimmune processes play in
rheumatoid arthritis (RA) pathogenesis has been widely proven. Given the easier …

Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications

T Kissel, S Reijm, LM Slot, M Cavallari… - Annals of the …, 2020 - ard.bmj.com
Objective Autoantibodies against antigens carrying distinct post-translational modifications
(PTMs), such as citrulline, homocitrulline or acetyllysine, are hallmarks of rheumatoid …

Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

K Amara, J Steen, F Murray, H Morbach… - Journal of Experimental …, 2013 - rupress.org
Antibodies targeting citrullinated proteins (ACPAs [anticitrullinated protein antibodies]) are
commonly found in patients with rheumatoid arthritis (RA), strongly associate with distinct …

[HTML][HTML] Clinical and pathophysiologic relevance of autoantibodies in rheumatoid arthritis

SB Rocha, DC Baldo, LEC Andrade - Advances in Rheumatology, 2019 - SciELO Brasil
Rheumatoid arthritis (RA) is an autoimmune/inflammatory disease affecting 0.5 to 1% of
adults worldwide and frequently leads to joint destruction and disability. Early diagnosis and …