Metastatic colorectal cancers (mCRCs) are clinically heterogeneous, but the genomic basis
of this variability remains poorly understood. We performed prospective targeted sequencing …

In contrast to primary colorectal cancer (CRC) little is known about the genomic landscape of
metastasized CRC. Here we present whole genome sequencing data of metastases of 429 …

Background Distant metastasis accounts for 90% of deaths from colorectal cancer (CRC).
Genomic heterogeneity has been reported in various solid malignancies, but remains …

BACKGROUND Early identification of mutations may guide patients with metastatic
colorectal cancer toward targeted therapies that may be life prolonging. The authors …

Purpose: The incidence rates of colorectal cancers are increasing in young adults. The
objective of this study was to investigate genomic differences between tumor samples …

Colorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its
mutational profile, we conduct targeted sequencing of 205 genes for 2,105 CRC cases with …

Background Colorectal cancer is the second leading cause of cancer death in the United
States, with over 50,000 deaths estimated in 2014. Molecular profiling for somatic mutations …

Approximately 50% of patients with primary colorectal carcinoma develop liver metastases.
Understanding the genetic differences between primary colon cancer and their metastases …

Purpose To compare the mutational and copy number profiles of primary and metastatic
colorectal carcinomas (CRCs) using both unpaired and paired samples derived from …

Introduction: Metastatic colorectal cancer (CRC) remains a dilemma for cancer researchers
with an increasing incidence in the younger patient population. Until the last decade, limited …