Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

Endothelial cells live in a dynamic environment, where they are constantly exposed to
external hemodynamic forces and generate cytoskeletal-based endogenous forces. These …

The endothelial cells (ECs) that line the inner layer of blood vessels are responsible for
maintaining vascular homeostasis under physiological conditions. In the presence of …

Significance: Forces are important in the cardiovascular system, acting as regulators of
vascular physiology and pathology. Residing at the blood vessel interface, cells (endothelial …

Endothelial cells (ECs) lining blood vessels express many mechanosensors, including
platelet endothelial cell adhesion molecule-1 (PECAM-1), that convert mechanical force into …

Blood and lymphatic vessels are lined by endothelial cells which constantly interact with
their luminal and abluminal extracellular environments. These interactions confer physical …

Vascular endothelial cells (ECs) play significant roles in regulating circulatory functions.
Mechanical stimuli, including the stretch and shear stress resulting from circulatory pressure …

Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …

Cardiovascular disease (CVD) is a serious health challenge, causing more deaths
worldwide than cancer. The vascular endothelium, which forms the inner lining of blood …

Blood vessels are constantly exposed to hemodynamic forces in the form of cyclic stretch
and shear stress due to the pulsatile nature of blood pressure and flow. Endothelial cells …