[HTML][HTML] Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …

Biodistribution of mesenchymal stem/stromal cells in a preclinical setting

L Sensebé, S Fleury-Cappellesso - Stem cells international, 2013 - Wiley Online Library
Due to their multi/pluripotency and immunosuppressive properties, mesenchymal
stem/stromal cells (MSCs) are important tools for treatment of immune disorders and tissue …

Mesenchymal stem/stromal cells: a new''cells as drugs''paradigm. Efficacy and critical aspects in cell therapy

L de Girolamo, E Lucarelli, G Alessandri… - Current …, 2013 - ingentaconnect.com
Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone
marrow. Currently MSCs may also be isolated from several alternative sources and they …

[HTML][HTML] Therapeutic mesenchymal stem/stromal cells: value, challenges and optimization

M Najar, R Melki, F Khalife, L Lagneaux… - Frontiers in cell and …, 2022 - frontiersin.org
Cellular therapy aims to replace damaged resident cells by restoring cellular and molecular
environments suitable for tissue repair and regeneration. Among several candidates …

[HTML][HTML] A brief overview of global trends in MSC-based cell therapy

D Jovic, Y Yu, D Wang, K Wang, H Li, F Xu… - Stem cell reviews and …, 2022 - Springer
Human mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or
medicinal signaling cells, are important adult stem cells for regenerative medicine, largely …

[HTML][HTML] Challenges and advances in clinical applications of mesenchymal stromal cells

T Zhou, Z Yuan, J Weng, D Pei, X Du, C He… - Journal of hematology & …, 2021 - Springer
Mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have been
intensely investigated for clinical applications within the last decades. However, the majority …

Revisiting the mesenchymal “stem vs. stromal” cell dichotomy and its implications for development of improved potency metrics

DG Phinney, R Hwa Lee, SV Boregowda - Stem Cells, 2023 - academic.oup.com
Mesenchymal stem/stromal cell (MSC)-based therapies have been evaluated in over 1500
human clinical trials for a diverse array of disease indication, but outcomes remain …

[HTML][HTML] Mesenchymal stromal cell therapeutic delivery: translational challenges to clinical application

H Caplan, SD Olson, A Kumar, M George… - Frontiers in …, 2019 - frontiersin.org
For several decades, multipotent mesenchymal stromal cells (MSCs) have been extensively
studied for their therapeutic potential across a wide range of diseases. In the preclinical …

[HTML][HTML] Mesenchymal stem cells: a new trend for cell therapy

X Wei, X Yang, Z Han, F Qu, L Shao… - Acta Pharmacologica …, 2013 - nature.com
Mesenchymal stem cells (MSCs), the major stem cells for cell therapy, have been used in
the clinic for approximately 10 years. From animal models to clinical trials, MSCs have …

[HTML][HTML] Mesenchymal stem/stromal cells: developmental origin, tumorigenesis and translational cancer therapeutics

C Li, H Zhao, B Wang - Translational oncology, 2021 - Elsevier
While a large and growing body of research has demonstrated that mesenchymal
stem/stromal cells (MSCs) play a dual role in tumor growth and inhibition, studies exploring …