Despite intensive surgical excision, radiation therapy, and chemotherapy, the current life
expectancy for patients diagnosed with glioblastoma multiforme is only 12 to 15 months …

Drug delivery to the central nervous system remains a challenging area of investigation for
both basic and clinical neuroscientists. Numerous drugs are generally excluded from blood …

Purpose. Delivery of chemotherapeutics using implantable, biodegradable polymers
provides a potentially powerful method of treating braintumors. The present studies …

Carboplatin is a potent anticancer agent that has shown efficacy in clinical trials against
malignant glioma, one of the most deadly cancers in humans. However, a high systemic …

Controlled-release drug delivery systems are capable of treating debilitating diseases,
including cancer. Brain cancer, in particular glioblastoma multiforme (GBM), is an extremely …

Purpose. Implantation of biodegradable polymers provides a powerfulmethod to deliver
high, sustained concentrations of chemotherapeuticsto brain tumors. The present studies …

Glioblastoma (GBM) is an aggressive malignant cancer associated with bleak prognosis and
high mortality. The current standard of care for GBM is maximum surgical resection plus …

OBJECTIVE: Local delivery of carmustine (BCNU) from biodegradable polymers prolongs
survival against experimental brain tumors. Moreover, paracrine administration of interleukin …

Glioblastoma multiforme (GBM), a type of malignant glioma, is the most common form of
brain cancer found in adults. The current standard of care for GBM involves adjuvant …

We have developed a systematic approach for the discovery and evaluation of local
treatment strategies for brain tumors using polymers. We demonstrated the feasibility of …