Abstract Significance: The 3-hydroxy-methylglutaryl coenzyme A reductase inhibitors or
statins are important therapeutic agents for lowering serum cholesterol levels. However …

Atherosclerosis is a complex inflammatory process characterized by the cross-talk between
excessive inflammation and lipid accumulation. In the past few years, compelling evidence …

ROCKs are important regulators of the actin cytoskeleton. Because changes in the actin
cytoskeleton underlie vascular contractility and remodeling, inflammatory cell recruitment …

BACKGROUND: In addition to inhibiting cholesterol synthesis, statins (HMG-CoA reductase
inhibitors) decrease the formation of isoprenoid intermediates required for the activation of …

The Rho kinase (ROCK) isoforms, ROCK1 and ROCK2, were initially discovered as
downstream targets of the small GTP-binding protein Rho. Because ROCKs mediate various …

Rho-associated coiled-coil forming protein kinases (ROCKs), the downstream target
proteins of RhoA, are ubiquitously expressed serine-threonine protein kinases. ROCKs have …

Rho-associated kinases (ROCKs), the immediate downstream targets of RhoA, are
ubiquitously expressed serine-threonine protein kinases that are involved in diverse cellular …

Rho-kinase (ROCK) is one of the effectors of the small GTP-binding protein Rho.
Accumulating evidence suggests that the Rho/ROCK system may play an important role in …

Background—By inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase, statins not
only reduce cholesterol biosynthesis but also decrease the formation of isoprenoids, which …

The Rho/rho-kinase (ROCK) pathway has an important role in the pathogenesis of several
cardiovascular diseases. The activation of ROCK is involved in the regulation of vascular …