[HTML][HTML] Coacervates as models of membraneless organelles

NA Yewdall, AAM André, T Lu, E Spruijt - Current Opinion in Colloid & …, 2021 - Elsevier
Coacervates are condensed liquid-like droplets, usually formed with oppositely charged
polymeric molecules. They have been studied extensively in colloid and interface science …

Biomolecular chemistry in liquid phase separated compartments

KK Nakashima, MA Vibhute, E Spruijt - Frontiers in molecular …, 2019 - frontiersin.org
Biochemical processes inside the cell take place in a complex environment that is highly
crowded, heterogeneous, and replete with interfaces. The recently recognized importance of …

Endocytosis of coacervates into liposomes

T Lu, S Liese, L Schoenmakers, CA Weber… - Journal of the …, 2022 - ACS Publications
Recent studies have shown that the interactions between condensates and biological
membranes are of functional importance. Here, we study how the interaction between …

Multiphasic coacervates assembled by hydrogen bonding and hydrophobic interactions

X Liu, AH Mokarizadeh, A Narayanan… - Journal of the …, 2023 - ACS Publications
Coacervation has emerged as a prevalent mechanism to compartmentalize biomolecules in
living cells. Synthetic coacervates help in understanding the assembly process and mimic …

Peptide-based coacervates as biomimetic protocells

M Abbas, WP Lipiński, J Wang, E Spruijt - Chemical Society Reviews, 2021 - pubs.rsc.org
Coacervates are condensed liquid-like droplets formed by liquid–liquid phase separation of
molecules through multiple weak associative interactions. In recent years it has emerged …

Peptide‐based coacervate‐core vesicles with semipermeable membranes

M Abbas, JO Law, SN Grellscheid… - Advanced …, 2022 - Wiley Online Library
Coacervates droplets have long been considered as potential protocells to mimic living
cells. However, these droplets lack a membrane and are prone to coalescence, limiting their …

The wide world of coacervates: from the sea to neurodegeneration

E Astoricchio, C Alfano, L Rajendran… - Trends in biochemical …, 2020 - cell.com
The formation of immiscible liquid phases or coacervates is a phenomenon widely observed
in biology. Marine organisms, for instance, use liquid–liquid phase separation (LLPS) as the …

Lipid vesicle-coated complex coacervates

F Pir Cakmak, AT Grigas, CD Keating - Langmuir, 2019 - ACS Publications
Compartmentalization by complex coacervation is important across a range of different fields
including subcellular and prebiotic organization, biomedicine, food science, and personal …

Multiphase complex coacervate droplets

T Lu, E Spruijt - Journal of the American Chemical Society, 2020 - ACS Publications
Liquid–liquid phase separation plays an important role in cellular organization. Many
subcellular condensed bodies are hierarchically organized into multiple coexisting domains …

Microfluidic formation of monodisperse coacervate organelles in liposomes

NN Deng, WTS Huck - Angewandte Chemie, 2017 - Wiley Online Library
Coacervates have been widely studied as model compartments in protocell research.
Complex coacervates composed of disordered proteins and RNA have also been shown to …