Mitochondria act as hubs of numerous metabolic pathways. Mitochondrial dysfunctions
contribute to altering the redox balance and predispose to aging and metabolic alterations …

Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …

In search for strategies aimed at preventing oxidative threat to female fertility, a possible role
of sirtuins has emerged. Sirtuins (silent information regulator 2 (Sir2) proteins), NAD+ …

Silent information Regulators (SIRT1) gene stimulates antioxidants' expression, repairs cells
damaged by oxidative stress (OS), and prevents the cells' dysfunction. In particular, the role …

Advancing age is the major risk factor for the development of chronic diseases and is
accompanied by changes in metabolic processes and mitochondrial dysfunction …

SIRT2, a member of the sirtuin family, has been recently shown to exert important effects on
mitosis and/or metabolism. However, its roles in oocyte maturation have not been fully …

Mammalian oocytes rely heavily on mitochondrial oxidative phosphorylation (OXPHOS) for
generating ATP. However, mitochondria are also the primary source of damaging reactive …

ABSTRACT SIRT7, a member of the sirtuin family, with coenzyme NAD catalyzes protein
deacetylation and has been implicated in multiple biologic processes; however, its function …

The current lifestyle of “western societies” is based on excessive consumption of high-
energy diets and physical inactivity. Such behavior has pressured biological systems …

Mitochondria are the metabolic hubs that process a number of reactions including
tricarboxylic acid cycle, β-oxidation of fatty acids and part of the urea cycle and pyrimidine …