Polyamine metabolism and oxidative protein folding in the ER as ROS-producing systems neglected in virology

OA Smirnova, B Bartosch, NF Zakirova… - International journal of …, 2018 - mdpi.com
Reactive oxygen species (ROS) are produced in various cell compartments by an array of
enzymes and processes. An excess of ROS production can be hazardous for normal cell …

Reactive oxygen species as potential antiviral targets

WJ Sander, C Fourie, S Sabiu… - Reviews in Medical …, 2022 - Wiley Online Library
Reactive oxygen species (ROS) are by‐products of cellular metabolism and can be either
beneficial, at low levels, or deleterious, at high levels, to the cell. It is known that several viral …

[HTML][HTML] The oxidative folding of nascent polypeptides provides electrons for reductive reactions in the ER

K Uegaki, Y Tokunaga, M Inoue, S Takashima, K Inaba… - Cell Reports, 2023 - cell.com
The endoplasmic reticulum (ER) maintains an oxidative redox environment that is
advantageous for the oxidative folding of nascent polypeptides entering the ER. Reductive …

[HTML][HTML] Respiratory viral infections and subversion of cellular antioxidant defenses

N Komaravelli, A Casola - Journal of pharmacogenomics & …, 2014 - ncbi.nlm.nih.gov
Reactive oxygen species (ROS) formation is part of normal cellular aerobic metabolism, due
to respiration and oxidation of nutrients in order to generate energy. Low levels of ROS are …

Endoplasmic reticulum-associated degradation potentiates the infectivity of influenza A virus by regulating the host redox state

KI Jung, DH Ko, N Shin, CW Pyo, SY Choi - Free Radical Biology and …, 2019 - Elsevier
During influenza A virus (IAV) infection, significant effects of oxidative stress often emerge
due to the disruption of the redox balance. Reactive oxygen species (ROS) generated …

Polyamines: small molecules with a big role in promoting virus infection

MMH Li, MR MacDonald - Cell host & microbe, 2016 - cell.com
Polyamines play important roles in a range of cellular processes. In this issue of Cell Host &
Microbe, Mounce et al.(2016) link polyamine metabolism to the interferon response and …

Good cop, bad cop: Polyamines play both sides in host immunity and viral replication

YE Cruz-Pulido, BC Mounce - Seminars in Cell & Developmental Biology, 2023 - Elsevier
Viruses rely on host cells for energy and synthesis machinery required for genome
replication and particle assembly. Due to the dependence of viruses on host cells, viruses …

The role of cellular oxidoreductases in viral entry and virus infection-associated oxidative stress: potential therapeutic applications

L Mathys, J Balzarini - Expert opinion on therapeutic targets, 2016 - Taylor & Francis
Introduction: Cellular oxidoreductases catalyze thiol/disulfide exchange reactions in
susceptible proteins and contribute to the cellular defense against oxidative stress …

Peroxiredoxins—the underrated actors during virus-induced oxidative stress

IL Karpenko, VT Valuev-Elliston, ON Ivanova… - Antioxidants, 2021 - mdpi.com
Enhanced production of reactive oxygen species (ROS) triggered by various stimuli,
including viral infections, has attributed much attention in the past years. It has been shown …

Perspectives on mechanistic implications of ROS inducers for targeting viral infections

R Nadhan, D Patra, N Krishnan, A Rajan… - European journal of …, 2021 - Elsevier
In this perspective, we propose to leverage reactive oxygen species (ROS) induction as a
potential therapeutic measure against viral infections. Our rationale for targeting RNA viral …