There is a growing interest in developing microphysiological systems that can be used to
model both normal and pathological human organs in vitro. This “organs-on-chips” …

Assessment of anti-cancer drug efficacy in in vitro three-dimensional (3D) bioengineered
cancer models provides important contextual and relevant information towards pre-clinical …

Around 95% of anti-cancer drugs that show promise during preclinical study fail to gain FDA-
approval for clinical use. This failure of the preclinical pipeline highlights the need for …

Tractable human tissue-engineered 3D models of cancer that enable fine control of tumor
growth, metabolism, and reciprocal interactions between different cell types in the tumor …

In vitro 3D culture systems provide promising tools for screening novel therapies and
understanding drug resistance mechanisms in cancer because they are adapted for high …

In vitro three-dimensional (3D) tumour models mimic natural cancer tissue in vivo, bridging
the gap between conventional 2D in vitro testing and animal models. Stromal and cancer …

The microvasculature plays a critical role in human physiology and is closely associated to
various human diseases. By combining advanced microfluidic-based techniques, the …

The hallmark of tumours is the ability of cancerous cells to promote vascular growth, to
disseminate and invade to distant organs. The metastatic process is heavily influenced by …

Most cancer treatment strategies target cell proliferation, angiogenesis, migration, and
intravasation of tumor cells in an attempt to limit tumor growth and metastasis. An in vitro …

The tumour microenvironment and tumour angiogenesis play a critical role in the
development and therapy of many cancers, but in vitro models reflecting these …