The conformationally restricted, cyclic, disulfide-containing, enkephalin analogs [2-D-
penicillamine, 5-L-penicillamine] enkephalin [(D-Pen2, L-Pen5] enkephalin) and [2-D …

The enkephalin analogs,[D-Pen 2, L-Cys 5]-and [D-Pen 2, D-Cys 5]-enkephalin are cyclic
compounds, conformationally constrained by virtue of their 14-membered, disulfide …

Specific binding properties of the tritium-labeled delta opiate receptor agonist [3H][2-D-
penicillamine, 5-D-penicillamine] enkephalin [(3H][D-Pen2, D-Pen5] enkephalin) were …

We have studied the receptor binding activities of C-terminal free and amidated enkephalins
with and without the dehydrophenylalanine 4 residue. For the selective labeling of so-called …

The enkephalins, dynorphins, and endorphins are endogenous opioids which function as
neurotransmitters, neuromodulators, and hormones and are involved in the perception of …

Introduction There is now overwhelming evidence from pharmacological considerations2" 4
and fromstructure-activity studies5 that the endogenous opioid peptides methionine …

[D-Ala2, Leu5, Cys6] Enkephalin (DALCE) is a synthetic enkephalin analog which contains
a sulfhydryl group. DALCE binds with high affinity to delta-receptors, with moderate affinity to …

Abstract Deltakephalin, Tyr-D-Thr-Gly-Phe-Leu-Thr (DTLET) was rationally designed as
pure δ-probe from proposed models of μ and δ opiate receptors. On peripheral organs …

A series of D-amino acid-substituted analogs of the opiate peptide, methionine 5-
enkephalin, were synthesized by solid-phase methods and tested for their abilities to inhibit …

To elucidate which portions of the opioid receptor molecules are involved in the ligand
selectivity, we have expressed chimeric receptors between the rat δ-and μ-opioid receptors …