Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by
diverse serological autoantibodies. Anti-dsDNA antibodies are involved in multiple organ …

Antibodies to dsDNA are specific to SLE and are pathogenic, both due to their ability to
deposit in tissues through a variety of mechanisms, and to their ability, when present in …

Systemic lupus erythematosus (SLE) is characterized by high-titer serological
autoantibodies, including antibodies that bind to double-stranded DNA (dsDNA). The origin …

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with
elevated morbidity and multi-organ involvement. While many strategies have shown efficacy …

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects most of
the organs and tissues of the body, causing glomerulonephritis, arthritis, and cerebritis. SLE …

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease. The presence
of a multitude of autoantibodies is a hallmark of the disease. In particular, autoantibodies …

Systemic lupus erythematosus (SLE) is a multisystem autoimmune rheumatic disease
characterized by the presence of autoantibodies, many of which are directed against …

Current therapies for treating systemic lupus erythematosus (SLE) mainly rely upon
nonspecific and toxic immunosuppression by corticosteroids and cytotoxics. Although …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple
organ inflammatory damage and wide spectrum of autoantibodies. The autoantibodies …

Self-reactive B cells generated through V (D) J recombination in the bone marrow or through
accrual of random mutations in secondary lymphoid tissues are mostly purged or edited to …