Experimental occlusal interference induces long-term masticatory muscle hyperalgesia in rats

Y Cao, QF Xie, K Li, AR Light, KY Fu - PAIN®, 2009 - Elsevier
Temporomandibular joint or related masticatory muscle pain represents the most common
chronic orofacial pain condition. Patients frequently report this kind of pain after dental …

[HTML][HTML] Central sensitization and MAPKs are involved in occlusal interference-induced facial pain in rats

Y Cao, K Li, KY Fu, QF Xie, CY Chiang, BJ Sessle - The Journal of Pain, 2013 - Elsevier
We previously developed a rat dental occlusal interference model of facial pain that was
produced by bonding a crown onto the right maxillary first molar and was reflected in …

Development of a rat model of mechanically induced tunable pain and associated temporomandibular joint responses

S Kartha, T Zhou, EJ Granquist… - Journal of Oral and …, 2016 - Elsevier
Purpose Although mechanical overloading of the temporomandibular joint (TMJ) is
implicated in TMJ osteoarthritis (OA) and orofacial pain, most experimental models of TMJ …

[PDF][PDF] A rat model of temporomandibular joint pain with histopathologic modifications

SB Nicoll, CK Hee, MB Davis… - Journal of orofacial …, 2010 - spinepain.seas.upenn.edu
Aims: To develop a rat model of temporomandibular joint (TMJ) pain and to characterize in it
the development and temporal response of behavioral hypersensitivity as well as to …

Role of TRPV 1 and ASIC 3 channels in experimental occlusal interference‐induced hyperalgesia in rat masseter muscle

XX Xu, Y Cao, TT Ding, KY Fu, Y Li… - European Journal of …, 2016 - Wiley Online Library
Background Masticatory muscle pain may occur following immediate occlusal alteration by
dental treatment. The underlying mechanisms are poorly understood. Transient receptor …

The difficult relationship between occlusal interferences and temporomandibular disorder–insights from animal and human experimental studies

Q Xie, X Li, X Xu - Journal of Oral Rehabilitation, 2013 - Wiley Online Library
The aetiology of temporomandibular disorder (TMD) is multifactorial, and numerous studies
have addressed that occlusion may be of great importance. However, whether occlusion …

Long lasting pain hypersensitivity following ligation of the tendon of the masseter muscle in rats: a model of myogenic orofacial pain

W Guo, H Wang, S Zou, F Wei, R Dubner… - Molecular …, 2010 - journals.sagepub.com
Background: A major subgroup of patients with temporomandibular joint (TMJ) disorders
have masticatory muscle hypersensitivity. To study myofacial temporomandibular pain, a …

No effect of experimental occlusal interferences on pressure pain thresholds of the masseter and temporalis muscles in healthy women

A Michelotti, M Farella, MH Steenks… - European journal of …, 2006 - Wiley Online Library
It has been suggested that occlusal interferences may lead to pain and tenderness of the
masticatory muscles. Tender jaw muscles are more sensitive to pressure pain, as assessed …

Sustained and repeated mouth opening leads to development of painful temporomandibular disorders involving macrophage/microglia activation in mice

GYF Wang, XQ Shi, W Wu, M Gueorguieva, M Yang… - Pain, 2018 - journals.lww.com
Temporomandibular disorder (TMD) is a set of heterogeneous musculoskeletal conditions
involving the temporomandibular joint (TMJ) and/or the masticatory muscles. Up to 33% of …

Nociceptive behavioural assessments in mouse models of temporomandibular joint disorders

J Li, K Ma, D Yi, C Oh, D Chen - International Journal of Oral Science, 2020 - nature.com
Orofacial pain or tenderness is a primary symptom associated with temporomandibular joint
(TMJ) disorders (TMDs). To understand the pathological mechanisms underlying TMDs …