Biological polyadenylation, first recognized as an enzymatic activity, remained an orphan
enzyme until poly A sequences were found on the 3′ ends of eukaryotic mRNAs. Their …

The 3′-ends of both prokaryotic and eukaryotic mRNA are polyadenylated, but the poly (A)
tracts of prokaryotic mRNA are generally shorter, ranging from 15 to 60 adenylate residues …

To study the mechanism and factors required to form the 3'ends of polyadenylated mRNAs,
we have fractionated HeLa cell nuclear extracts carrying out the normally coupled cleavage …

Almost all messenger RNAs carry a polyadenylate tail that is added in a post‐transcriptional
reaction. In the nuclei of animal cells, the 3'‐end of the RNA is formed by endonucleolytic …

Poly (A) tails of mRNA are nearly ubiquitous. In animal cells, the only mRNAs known to lack
poly (A) are those encoding the major histones (1-3). Poly (A) tails also occur in plants and …

Post-transcriptional addition of poly (A) tails to the 3′ end of RNA is one of the fundamental
events controlling the functionality and fate of RNA in all kingdoms of life. Although an …

Nearly every eukaryotic mRNA contains a poly (A) tail at its 3′ end. Unlike the factors that
catalyze other RNA processing reactions, the basal polyadenylation machinery consist …

Polyadenylation of mRNA precursors by poly (A) polymerase depends on two specificity
factors and their recognition sequences. These are cleavage and polyadenylation specificity …

A poly (A) tail is found at the 3 end of nearly every fully processed eukaryotic mRNA and has
been suggested to influence virtually all aspects of mRNA metabolism. Its proposed …

Most eukaryotic mRNAs have a poly (A) tail added onto their 3'ends, probably as an early
step in the maturation of the primary transcript. This process involves both cleavage of the …