Converting genetic information into functional proteins is a complex, multi-step process, with
each step being tightly regulated to ensure the accuracy of translation, which is critical to …

During protein synthesis, translating ribosomes encounter many challenges imposed by
various types of defective mRNAs that can lead to reduced cellular fitness and, in some …

Stalling of ribosomes engaged in protein synthesis can lead to significant defects in the
function of newly synthesized proteins and thereby impair protein homeostasis …

The correct decoding of messenger RNAs (mRNAs) into proteins is an essential cellular
task. The translational process is monitored by several quality control (QC) mechanisms that …

The translation machinery and the genes it decodes co-evolved to achieve production
throughput and accuracy. Nonetheless, translation errors are frequent, and they affect …

Translation fidelity is the limiting factor in the accuracy of gene expression. With an
estimated frequency of 10− 4, errors in mRNA decoding occur in a mostly stochastic manner …

Accurate gene expression is a prerequisite for all cellular processes. Quality control
machineries respond to errors during protein synthesis by refolding polypeptides or …

The cell monitors and maintains the fidelity of translation during the three stages of protein
synthesis: initiation, elongation and termination. Errors can arise by multiple mechanisms …

The importance of translation fidelity has been apparent since the discovery of genetic code.
It is commonly believed that translation deviating from the main coding region is to be …

Protein misfolding is increasingly being recognized as a key process in organismal health
and disease. Drummond and Wilke (2008) show that misfolding caused by mistakes during …