Extracellular proteolysis is an absolute requirement for new blood vessel formation
(angiogenesis). This review examines the role of the matrix metalloproteinase (MMP) and …

New blood formation or angiogenesis has become a key target in therapeutic strategies
aimed at inhibiting tumor growth and other diseases associated with neovascularization …

In the initial stages of capillary formation (angiogenesis) microvascular endothelial cells of
preexisting blood vessels locally degrade the underlying basal lamina and invade into the …

The urokinase‐type plasminogen activator (uPA) and the matrix‐degrading
metalloproteinases MMP‐2 and MMP‐9 (type IV collagenases/gelatinases) have been …

Following malignant transformation, tumor cells and their surrounding stroma produce a
variety of growth factors and proteolytic enzymes to induce new capillary formation …

Vascular remodeling, defined as lasting structural changes in the vessel wall in response to
hemodynamic stimuli, plays a role in many (patho) physiological processes requiring cell …

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) play a
significant role in regulating angiogenesis, the process of new blood vessel formation …

Extracellular proteolysis is required for matrix degradation and the regulation of cytokine
activity during angiogenesis, and this is dependent on a cohort of proteases and protease …

A number of extensive reviews are available discussing the roles of MMPs in various
aspects of cancer progression from benign tumor formation to overt cancer present with …

Matrix metalloproteinases (MMPs) constitute a large family of extracellular matrix degrading
proteases implicated in a number of physiological and pathological processes, including …