Cellular immunity is critical for controlling intracellular pathogens, but individual cellular
dynamics and cell–cell cooperativity in evolving human immune responses remain poorly …

The twenty-first century has seen the emergence of many epidemic and pandemic viruses,
with the most recent being the SARS-CoV-2-driven COVID-19 pandemic. As obligate …

Advances in single-cell RNA sequencing (scRNA-seq) have allowed for comprehensive
analysis of the immune system. In this Review, we briefly describe the available scRNA-seq …

Complex interactions between different host immune cell types can determine the outcome
of pathogen infections. Advances in single cell RNA-sequencing (scRNA-seq) allow probing …

The immune system is composed of a complex hierarchy of cell types that protect the
organism against disease and maintain homeostasis. Identifying heterogeneity of immune …

Despite effective treatment, HIV can persist in latent reservoirs, which represent a major
obstacle toward HIV eradication. Targeting and reactivating latent cells is challenging due to …

Understanding the drivers and markers of clonally expanding HIV-1-infected CD4+ T cells is
essential for HIV-1 eradication. We used single-cell ECCITE-seq, which captures surface …

Recent advances in single-cell technologies, particularly single-cell RNA-sequencing
(scRNA-seq), have permitted high throughput transcriptional profiling of a wide variety of …

In the early stages of viral infection, outcomes depend on a race between expansion of
infection and the immune response generated to contain it. We combined in situ tetramer …

Cells require coordinated control over gene expression when responding to environmental
stimuli. Here we apply scATAC-seq and single-cell RNA sequencing (scRNA-seq) in resting …