The 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway for isoprenoid biosynthesis has
come under increased scrutiny as a target for novel antimalarial, antibacterial and herbicidal …

The methylerythritol phosphate pathway to isoprenoids, an alternate biosynthetic route
present in many bacteria, algae, plants, and the malarial parasite Plasmodium falciparum …

The non-mevalonate or 2-C-methyl-d-erythritol-4-phosphate (MEP) pathway is responsible
for generating isoprenoid precursors in plants, protozoa, and bacteria. Because this pathway …

Isoprenoid biosynthesis via the methylerythritol phosphate pathway is a target against
pathogenic bacteria and the malaria parasite Plasmodium falciparum. 4-(Hydroxyamino)-4 …

1-Deoxy-d-xylulose-5-phosphate reductoisomerase (DXR) in the nonmevalonate isoprene
biosynthesis pathway is a target for developing antimalarial drugs. Fosmidomycin, a potent …

Isoprene biosynthesis is an essential component of metabolism. Two pathways are known
for the production of five-carbon (isoprene) intermediates: the mevalonate and …

Important pathogens such as Mycobacterium tuberculosis and Plasmodium falciparum, the
causative agents of tuberculosis and malaria, respectively, and plants, utilize the 2 C-methyl …

The key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis, 1-deoxy-d-
xylulose 5-phosphate reductoisomerase (DXR) has been shown to be the target enzyme of …

Fosmidomycin, a potent inhibitor of 1-deoxy-d-xylulose-5-phosphate reductoisomerase
(DXR), has antibacterial and antimalaria activity. Due to its poor pharmacokinetics, more …

IPP (isopentenyl diphosphate) and DMAPP (dimethylallyl diphosphate) serve as the
universal precursors for the biosynthesis of isoprenoids. Besides the well-known …