The TOR (target of rapamycin) signaling pathway and the transcriptional factor Myc play
important roles in growth control. Myc acts, in part, as a downstream target of TOR to …

In all eukaryotic organisms, the control of growth, metabolism, reproduction, and lifespan is
realized by interactions of genetic and environmental signals. An important player in the …

Precise regulation of stem cell activity is crucial for tissue homeostasis and necessary to
prevent overproliferation. In the Drosophila adult gut, high levels of reactive oxygen species …

Intestinal stem cells (ISCs) in the Drosophila adult midgut are essential for maintaining
tissue homeostasis, and their proliferation and differentiation speed up in order to meet the …

Intestinal homeostasis requires precise control of intestinal stem cell (ISC) proliferation. In
Drosophila, this control declines with age largely due to chronic activation of stress signaling …

A metabolic transition from glycolysis to oxidative phosphorylation is often associated with
differentiation of many types of stem cells. However, the link between mitochondrial …

Many tissues in higher animals undergo dynamic homeostatic growth, wherein damaged or
aged cells are replaced by the progeny of resident stem cells. To maintain homeostasis …

Adult tissue homeostasis requires a tight balance between the removal of old or damaged
cells and the production of new ones. Such processes are usually driven by dedicated stem …

The digestive tract is subjected to many aggressions throughout animal life. Since
disruptions of gut physiology impact on animal fitness and survival, maintenance of gut …

Precise control of somatic stem cell proliferation is crucial to ensure maintenance of tissue
homeostasis in high-turnover tissues. In Drosophila, intestinal stem cells (ISCs) are essential …