Vitamin B12–dependent taurine synthesis regulates growth and bone mass

P Roman-Garcia, I Quiros-Gonzalez… - The Journal of …, 2014 - Am Soc Clin Investig
Both maternal and offspring-derived factors contribute to lifelong growth and bone mass
accrual, although the specific role of maternal deficiencies in the growth and bone mass of …

Taurine inhibits osteoclastogenesis through the taurine transporter

LQ Yuan, W Liu, RR Cui, D Wang, JC Meng, H Xie… - Amino Acids, 2010 - Springer
Several studies have suggested a direct link between taurine and bone homeostasis.
However, the mechanisms of taurine on the regulation of bone metabolism have not been …

Taurine, an osteocyte metabolite, protects against oxidative stress-induced cell death and decreases inhibitors of the Wnt/β-catenin signaling pathway

M Prideaux, Y Kitase, M Kimble, TM O'Connell… - Bone, 2020 - Elsevier
Taurine has been shown to have positive effects on bone mass, which are thought to be due
in part to its cytoprotective effects on osteoblasts and here we show that taurine also protects …

Vitamin B12 Deficiency Stimulates Osteoclastogenesis via Increased Homocysteine and Methylmalonic Acid

BLT Vaes, C Lute, HJ Blom, N Bravenboer… - Calcified tissue …, 2009 - Springer
The risk of nutrient deficiencies increases with age in our modern Western society, and
vitamin B 12 deficiency is especially prevalent in the elderly and causes increased …

Taurine promotes connective tissue growth factor (CTGF) expression in osteoblasts through the ERK signal pathway

LQ Yuan, Y Lu, XH Luo, H Xie, XP Wu, EY Liao - Amino acids, 2007 - Springer
Taurine is found in bone tissue, but its function in skeletal tissue is not fully understood. The
present study was undertaken to investigate regulation of gene expression of connective …

Stimulation of ERK2 by taurine with enhanced alkaline phosphatase activity and collagen synthesis in osteoblast-like UMR-106 cells

S Park, H Kim, SJ Kim - Biochemical pharmacology, 2001 - Elsevier
Taurine is present in a variety of tissues and exhibits many important physiological functions
in the cell. Even though its functions are well documented in many tissues, its actions on …

[HTML][HTML] Taurine increases cell proliferation and generates an increase in [Mg2+] i accompanied by ERK 1/2 activation in human osteoblast cells

SH Jeon, MY Lee, SJ Kim, SG Joe, GB Kim, IS Kim… - FEBS letters, 2007 - Elsevier
Taurine has been reported to influence bone metabolism, and its specific transport system,
the taurine transporter, is expressed in osteoblasts. The mean [Mg2+] i was 0.51±0.01 mM in …

Taurine promotes human mesenchymal stem cells to differentiate into osteoblast through the ERK pathway

C Zhou, X Zhang, L Xu, T Wu, L Cui, D Xu - Amino Acids, 2014 - Springer
Taurine has been reported to influence bone metabolism, but the role of taurine on
osteogenic differentiation of human mesenchymal stem cells (hMSCs) remains unclear. In …

Low Plasma Vitamin B12 Is Associated With Lower BMD: The Framingham Osteoporosis Study

KL Tucker, MT Hannan, N Qiao… - Journal of Bone and …, 2005 - academic.oup.com
Vitamin B12 is important to DNA synthesis and may affect bone formation. We examined the
association between this vitamin and BMD in 2576 adults. Men with plasma B12< 148 pM …

B12 in fetal development

MR Pepper, MM Black - Seminars in cell & developmental biology, 2011 - Elsevier
Vitamin B12 (cobalamin) is necessary for development of the fetus and child. Pregnant
women who are vegetarian or vegan, have Crohn's or celiac disease, or have undergone …