A non-coding genetic variant associated with abdominal aortic aneurysm alters ERG gene regulation
Abdominal aortic aneurysm (AAA) is a major cause of sudden death in the elderly. While
AAA has some overlapping genetic and environmental risk factors with atherosclerosis …
AAA has some overlapping genetic and environmental risk factors with atherosclerosis …
Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci
Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and
environmental risk factors. Together, 6 previously identified risk loci only explain a small …
environmental risk factors. Together, 6 previously identified risk loci only explain a small …
Genetic architecture of abdominal aortic aneurysm in the million veteran program
Background: Abdominal aortic aneurysm (AAA) is an important cause of cardiovascular
mortality; however, its genetic determinants remain incompletely defined. In total, 10 …
mortality; however, its genetic determinants remain incompletely defined. In total, 10 …
Genetic and epigenetic mechanisms and their possible role in abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) is a common disease associated with significant
cardiovascular morbidity and mortality. The pathogenesis of AAA is poorly defined, making …
cardiovascular morbidity and mortality. The pathogenesis of AAA is poorly defined, making …
Genomic research to identify novel pathways in the development of abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) is a common disease with a large heritable component.
There is a need to improve our understanding of AAA pathogenesis in order to develop …
There is a need to improve our understanding of AAA pathogenesis in order to develop …
Genetic risk factors for abdominal aortic aneurysms (AAA)
Abdominal aortic aneurysm (AAA) is a complex, multifactorial disease with a strong genetic
component. About 20% of AAA patients have at least one relative with this condition. Since …
component. About 20% of AAA patients have at least one relative with this condition. Since …
Systematic review of genome-wide association studies of abdominal aortic aneurysm
Background and aims Abdominal aortic aneurysm (AAA) is an important cause of death
worldwide and has an estimated heritability between 70 and 77%. Genome-wide …
worldwide and has an estimated heritability between 70 and 77%. Genome-wide …
The transcription factor ERG regulates super-enhancers associated with an endothelial-specific gene expression program
V Kalna, Y Yang, CR Peghaire, K Frudd… - Circulation …, 2019 - Am Heart Assoc
Rationale: The ETS (E-26 transformation-specific) transcription factor ERG (ETS-related
gene) is essential for endothelial homeostasis, driving expression of lineage genes and …
gene) is essential for endothelial homeostasis, driving expression of lineage genes and …
Genetic insights into therapeutic targets for aortic aneurysms: A Mendelian randomization study
Y Chen, X Xu, L Wang, K Li, Y Sun, L Xiao, J Dai… - …, 2022 - thelancet.com
Summary Background As aortic aneurysms (AAs) enlarge, they can become life-threatening
if left undiagnosed or neglected. At present, there is a lack of radical treatments for …
if left undiagnosed or neglected. At present, there is a lack of radical treatments for …
A multi-locus genetic risk score for abdominal aortic aneurysm
Background We investigated whether a multi-locus genetic risk scores (GRS) was
associated with presence and progression of abdominal aortic aneurysm (AAA) in a case …
associated with presence and progression of abdominal aortic aneurysm (AAA) in a case …