Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation

H Pan, Y Wang, K Na, Y Wang, L Wang, Z Li… - Cell death & …, 2019 - nature.com
Targeting autophagy may serve as a promising strategy for cancer therapy. Ganoderma
lucidum polysaccharide (GLP) has been shown to exert promising anti-cancer effects …

Triterpenes From Ganoderma Lucidum Induce Autophagy in Colon Cancer Through the Inhibition of p38 Mitogen-Activated Kinase (p38 MAPK)

A Thyagarajan, A Jedinak, H Nguyen, C Terry… - Nutrition and …, 2010 - Taylor & Francis
Medicinal mushroom Ganoderma lucidum is one of the most esteemed natural products that
have been used in the traditional Chinese medicine. In this article, we demonstrate that G …

Effect of Ganoderma applanatum polysaccharides on MAPK/ERK pathway affecting autophagy in breast cancer MCF-7 cells

X Hanyu, L Lanyue, D Miao, F Wentao… - International journal of …, 2020 - Elsevier
Fungal polysaccharides have become hotspots in the field of health foods due to their
antitumor activity in recent years. In this experiment, antitumor effect of the medicinal fungus …

[HTML][HTML] Polysaccharide from spore of Ganoderma lucidum ameliorates paclitaxel-induced intestinal barrier injury: Apoptosis inhibition by reversing microtubule …

D Li, L Gao, M Li, Y Luo, Y Xie, T Luo, L Su… - Biomedicine & …, 2020 - Elsevier
Side effects of chemotherapy are burning questions for physicians and patients involved in
cancers. Ganoderma lucidum is a widely consumed traditional Chinese medicine and edible …

Ganoderma atrum polysaccharide ameliorates intestinal mucosal dysfunction associated with autophagy in immunosuppressed mice

M Ying, B Zheng, Q Yu, K Hou, H Wang, M Zhao… - Food and Chemical …, 2020 - Elsevier
The aim of this study was to investigate the protective effect and underlying mechanisms of
Ganoderma atrum polysaccharide (PSG-1) on cyclophosphamide (Cy)-induced intestinal …

Agrocybe cylindracea fucoglucogalactan induced lysosome-mediated apoptosis of colorectal cancer cell through H3K27ac-regulated cathepsin D

Z Wang, K Chen, K Zhang, K He, D Zhang, X Guo… - Carbohydrate …, 2023 - Elsevier
Inducing lysosomal dysfunction is emerging as a promising means for cancer therapy.
Agrocybe cylindracea fucoglucogalactan (ACP) is a bioactive ingredient with anti-tumor …

Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum

IL Hsin, GT Sheu, MS Jan, HL Sun… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE Autophagic cell death is considered a self‐destructive
process that results from large amounts of autophagic flux. In our previous study, GMI, a …

Inhibition of migration and induction of apoptosis in LoVo human colon cancer cells by polysaccharides from Ganoderma lucidum

ZE Liang, YJ Yi, YT Guo, RC Wang… - Molecular …, 2015 - spandidos-publications.com
Ganoderma lucidum polysaccharides (GLPs), which were purified from the medicinal herb
G. lucidum followed by ethanol precipitation, protein depletion using the Sevage assay …

Aloe gel glucomannan induced colon cancer cell death via mitochondrial damage-driven PINK1/Parkin mitophagy pathway

K Zhang, D Zhang, J Wang, Y Wang, J Hu, Y Zhou… - Carbohydrate …, 2022 - Elsevier
Mitophagy can selectively remove damaged mitochondria, which is critical in regulating
mitochondrial homeostasis in diseases, such as cancer. Herein, we found that Aloe gel …

[HTML][HTML] Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis

N Zhang, F Peng, Y Wang, L Yang, F Wu… - … Journal of Biological …, 2020 - ncbi.nlm.nih.gov
Colorectal carcinoma (CRC) is the third most common malignant tumor pathology
worldwide. Despite progress in surgical procedures and therapy options, CRC is still a …