In recent years, substantial advances have been made in the engineering of glycosidases
and glycosyltransferases for the synthesis and degradation of glycan structures. Key …

Vertebrate glycoproteins and glycolipids are synthesized in complex biosynthetic pathways
localized predominantly within membrane compartments of the secretory pathway. The …

The therapeutic potential of glycosides has made them an attractive target for drug
development. The biological extraction and chemical synthesis of these molecules is often …

Carbohydrates are known to play essential roles in a myriad of biological processes. The
enormous complexity of the various oligosaccharide structures found in biology is derived …

Cellular glycome assembly requires the coordinated action of a large number of
glycosyltransferases that catalyse the transfer of a sugar residue from a donor to specific …

Until recently, glycosidases, naturally hydrolyzing carbohydrate-active enzymes, have found
few synthetic applications in industry, being primarily used for cleaving unwanted …

Glycosyltransferases (GTs) are ubiquitous in nature and are required for the transfer of
sugars to a variety of important biomolecules. This essential enzyme family has been a focus …

The enzyme-catalysed degradation of oligo and polysaccharides is of considerable interest
in many fields ranging from the fundamental–understanding the intrinsic chemical beauty …

A robust platform for facile defined glycan synthesis does not exist. Yet the need for such
technology has never been greater as researchers seek to understand the full scope of …

Glycans linked to proteins and lipids play key roles in biology; thus, accurate replication of
cellular glycans is crucial for maintaining function following cell division. The fact that …