Approximately a quarter of a billion people around the world suffer from malaria each year.
Most cases are located in sub-Saharan Africa where Anopheles gambiae mosquitoes are …

► Genome editing is a new, cheap and versatile technique which has great promise to
combat vector-borne diseases. The current ethical debate worldwide is mainly concentrating …

Reducing the incidence of malaria has been a public health priority for nearly a century.
New technologies and associated vector control strategies play an important role in the …

CRISPR Cas9-powered gene drive allows for the rapid alteration of malaria-causing
mosquitoes to spread an infertility gene or resistance to malaria among their species …

Background The development of the CRISPR/Cas9 gene editing system has generated new
possibilities for the use of gene drive constructs to reduce or suppress mosquito populations …

Background Population suppression gene drive has been proposed as a strategy for
malaria vector control. A CRISPR-Cas9-based transgene homing at the doublesex locus …

This reprint is provided for personal and noncommercial use. For any other use, please send
a request to Permissions, American Scientist, PO Box 13975, Research Triangle Park, NC …

Background Population suppression gene drive is currently being evaluated, including via
environmental risk assessment (ERA), for malaria vector control. One such gene drive …

Innovative tools are essential for advancing malaria control and depend on an
understanding of molecular mechanisms governing transmission of malaria parasites by …

While considerable progress has been made in combating malaria, largely due to mosquito
control measures such as insecticides, the disease is still a major burden and the inability of …